Differential effect of the rs4149056 variant in SLCO1B1 on myopathy associated with simvastatin and atorvastatin
| Autor: | Liam R. Brunham, G.K. Hovingh, P. J. Lansberg, Michael R. Hayden, Johan Wouter Jukema, Cedric J. Carter, Lin-Hua Zhang, Anton F. H. Stalenhoef, Colin J. D. Ross, Henk Visscher, John J. P. Kastelein, Bruce Carleton, Fudan Miao |
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| Přispěvatelé: | Vascular Medicine, ACS - Amsterdam Cardiovascular Sciences |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Statin medicine.drug_class Atorvastatin Pharmacology Internal medicine Genetics Medicine cardiovascular diseases Myopathy Health aging / healthy living Cardiovascular diseases [IGMD 5] biology business.industry Case-control study statin nutritional and metabolic diseases Odds ratio SLCO1B1 Simvastatin Cohort biology.protein Molecular Medicine lipids (amino acids peptides and proteins) medicine.symptom business medicine.drug myopathy |
| Zdroj: | Pharmacogenomics Journal, 12, 233-7 pharmacogenomics journal, 12(3), 233-237. Nature Publishing Group Pharmacogenomics Journal, 12, 3, pp. 233-7 |
| ISSN: | 1470-269X |
| Popis: | Statins reduce cardiovascular morbidity and mortality in appropriately selected patients. However, statin-associated myopathy is a significant risk associated with these agents. Recently, variation in the SLCO1B1 gene was reported to predict simvastatin-associated myopathy. The aim of this study was to replicate association of the rs4149056 variant in SLCO1B1 with severe statin-associated myopathy in a cohort of patients using a variety of statin medications and to investigate the association with specific statin types. We identified 25 cases of severe statin-associated myopathy and 84 controls matched for age, gender, statin type and dose. The rs4149056 variant in SLCO1B1 was not significantly associated with myopathy in this group as a whole. However, when subjects were stratified by statin type, the SLCO1B1 rs4149056 genotype was significantly associated with myopathy in patients who received simvastatin, but not in patients who received atorvastatin. Our findings provide further support for a role for SLCO1B1 genotype in simvastatin-associated myopathy, and suggest that this association may be stronger for simvastatin compared with atorvastatin. The Pharmacogenomics Journal (2012) 12, 233-237; doi: 10.1038/tpj.2010.92; published online 18 January 2011 |
| Databáze: | OpenAIRE |
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