Adaptive immune regulation in autoimmune diabetes
| Autor: | Antonio La Cava, Concetta Ferretti |
|---|---|
| Přispěvatelé: | Ferretti, C., La Cava, A. |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
endocrine system Type 1 diabete endocrine system diseases Immunology Disease Adaptive Immunity Biology T-Lymphocytes Regulatory Pathogenesis Islets of Langerhans 03 medical and health sciences 0302 clinical medicine Immune system medicine Genetic predisposition Animals Humans Immunology and Allergy Regulatory T-cell immunotherapy Autoimmune disease Type 1 diabetes Animal Pancreatic islets nutritional and metabolic diseases Islets of Langerhan medicine.disease Acquired immune system Immunity Innate Diabetes Mellitus Type 1 030104 developmental biology medicine.anatomical_structure β-Cell Human 030215 immunology |
| Zdroj: | Autoimmunity Reviews. 15:236-241 |
| ISSN: | 1568-9972 |
| DOI: | 10.1016/j.autrev.2015.11.008 |
| Popis: | Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by the loss of insulin-producing pancreatic β-cells. The pathogenesis of T1D is complex and multifactorial and involves a genetic susceptibility that predisposes to abnormal immune responses in the presence of ill-defined environmental insults to the pancreatic islets. This review discusses how adaptive immunoregulatory T cells contribute to the modulation of the development and evolution of T1D, together with potential approaches that target these cells for new therapies in the disease. |
| Databáze: | OpenAIRE |
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