Energetic and thermodynamical aspects of the cyclodextrins-cannabidiol complex in aqueous solution: a molecular-dynamics study

Autor:	A. J. da Silva, E S Dos Santos
Rok vydání:	2020
Předmět:	0301 basic medicine 030103 biophysics Entropy Biophysics Molecular Dynamics Simulation 03 medical and health sciences Entropy (classical thermodynamics) Molecular dynamics medicine Cannabidiol Molecule Computer Simulation Dronabinol Lactic Acid Poisson Distribution chemistry.chemical_classification Cyclodextrins Aqueous solution Cyclodextrin Temperature Water General Medicine Interaction energy Hydrophobe Molecular Docking Simulation 030104 developmental biology Solubility chemistry Chemical physics Thermodynamics Algorithms medicine.drug
Zdroj:	European Biophysics Journal. 49:571-589
ISSN:	1432-1017 0175-7571
DOI:	10.1007/s00249-020-01463-8
Popis:	Cyclodextrins (CDs) are well-known carriers for encapsulating hydrophobic molecules, while among cannabinoids, cannabidiol (CBD) has attracted considerable attention due to its therapeutic capability. In this framework, we employed molecular dynamics and docking techniques for investigating the interaction energy and thermodynamical issues between different CDs (α, β, and γ type) and CBD immersed in water and a solution mimicking a physiological environment. We quantified the energetic aspects, for different thermal conditions, in which both aqueous solutions interact with CBDs and CDs and the CBD-CDs complex itself. In order to approximate the physiological conditions, our simulations also included the mammalian temperature. The calculations revealed significant interaction energy between lactate and the CD surface and a movement of lactate toward CD as well. We observed an almost constant number of lactate molecules forming clusters without exhibiting a temperature dependence. Next, the degree of CBD-CDs complexation at four different temperatures was analyzed. The results showed that the complexation depends on the medium, becoming weaker with the temperature increment. Our findings highlighted that the entropy contribution is relevant for CBD-α-CD and CBD-β-CD, while CBD-γ-CD is practically insensitive to temperature changes for both solutions. In both water and artificial physiological solutions, the γ-CD appears more stable than the other complexes. Overall, CBD achieved partial encapsulation considering α-CD and β-CD, showing a temperature dependence, while γ-CD remained fully immersed no matter the thermal level assumed. We also discuss the pharmacological relevance and physiological implications of these findings.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03eb4aa21b70628a55e12a6f2a9a0133 https://doi.org/10.1007/s00249-020-01463-8 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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