Amantadine in chronic granulomatous disease
| Autor: | Francesca Gombac, Marlenka Zerial, Valentina Leone, Alberto Tommasini, Loredana Lepore, Alessandro Ventura, Roberta Ciambra, Marilena Granzotto |
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| Přispěvatelé: | Granzotto, M, Leone, V, Lepore, L, Zerial, M, Tommasini, A, Ciambra, R, Gombac, F, Ventura, Alessandro |
| Rok vydání: | 2005 |
| Předmět: |
Drug
Adult Male Cultured Drug Evaluation Granulomatous Disease Neutrophils Phagocytosis media_common.quotation_subject Cells Opportunistic Infections Granulomatous Disease Chronic Adult Amantadine Candida albicans Case-Control Studies Cell Chronic granulomatous disease Adult Amantadine Candida albicans Case-Control Studies Cells Chronic Humans Hydrogen-Ion Concentration Kinetics Male Neutrophils Opportunistic Infections Phagocytosis Phagosomes hemic and lymphatic diseases Phagosomes Candida albicans medicine Amantadine Humans Chronic Immunodeficiency Cells Cultured media_common Phagosome Cultured biology business.industry Hematology Hydrogen-Ion Concentration biology.organism_classification medicine.disease Respiratory burst Kinetics Oncology Case-Control Studies Pediatrics Perinatology and Child Health Immunology Drug Evaluation Granulomatous Disease business medicine.drug |
| Zdroj: | Pediatric hematology and oncology. 22(2) |
| ISSN: | 0888-0018 |
| Popis: | Chronic granulomatous disease (CGD) is a rare genetically determined immunodeficiency. Neutrophils from CGD patients show a defective killing of phagocytosed fungi and bacteria, due not only to an impairment in oxidative burst, but also to absence of normal pH value within phagocytic vacuole following phagocytosis. Because a weak base such as amantadine could potentially reverse these pH abnormalities, the authors used this drug to treat 2 CGD patients. They observed modifications of both phagosomal pH and killing activity on their neutrophils compared to those of healthy controls. Since the drug has been employed, the patients have not developed new infections, suggesting a role of amantadine as a part of CGD prophylactic regimen. These results suggest the opportunity of testing the drug in larger studies. |
| Databáze: | OpenAIRE |
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