Assessment of metastatic colorectal cancer with hybrid imaging: comparison of reading performance using different combinations of anatomical and functional imaging techniques in PET/MRI and PET/CT in a short case series
| Autor: | C la Fougère, Hansjörg Rempp, Christina Pfannenberg, Konstantin Nikolaou, Nina F. Schwenzer, Christina Schraml, Holger Schmidt, Cornelia Brendle |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Colorectal cancer Multimodal Imaging 030218 nuclear medicine & medical imaging Lesion Young Adult 03 medical and health sciences 0302 clinical medicine Fluorodeoxyglucose F18 medicine Humans Radiology Nuclear Medicine and imaging Neoplasm Metastasis Child Lymph node Retrospective Studies PET-CT medicine.diagnostic_test business.industry Magnetic resonance imaging General Medicine Middle Aged medicine.disease Functional imaging Diffusion Magnetic Resonance Imaging medicine.anatomical_structure Positron emission tomography Positron-Emission Tomography 030220 oncology & carcinogenesis Female Radiology medicine.symptom Colorectal Neoplasms Tomography X-Ray Computed business Diffusion MRI |
| Zdroj: | European Journal of Nuclear Medicine and Molecular Imaging. 43:123-132 |
| ISSN: | 1619-7089 1619-7070 |
| DOI: | 10.1007/s00259-015-3137-z |
| Popis: | The purpose was to investigate the diagnostic performance of different combinations of anatomical and functional imaging techniques in PET/MRI and PET/CT for the evaluation of metastatic colorectal cancer lesions. Image data of 15 colorectal cancer patients (FDG-PET/CT and subsequent FDG-PET/MRI) were retrospectively evaluated by two readers in five reading sessions: MRI (morphology) alone, MRI/diffusion-weighted MRI (DWI), MRI/PET, MRI/DWI/PET; and PET/CT. Diagnostic performance of lesion detection with each combination was assessed in general and organ-based. The reference standard was given by histology and/or follow-up imaging. Separate analysis of mucinous tumours was performed. One hundred and eighty lesions (110 malignant) were evaluated (intestine n = 6, liver n = 37, lymph nodes n = 55, lung n = 4, and peritoneal n = 74). The overall lesion-based diagnostic accuracy was 0.46 for MRI, 0.47 for MRI/DWI, 0.57 for MRI/PET, 0.69 for MRI/DWI/PET and 0.66 for PET/CT. In the organ-based assessment, MRI/DWI/PET showed the highest accuracy for liver metastases (0.74), a comparable accuracy to PET/CT in peritoneal lesions (0.55), and in lymph node metastases (0.84). The accuracy in mucinous tumour lesions was limited in all modalities (MRI/DWI/PET = 0.52). PET/MRI including DWI is comparable to PET/CT in the evaluation of colorectal cancer metastases, with a markedly higher accuracy when using combined imaging data than the modalities separately. Further improvement is needed in the imaging of peritoneal carcinomatosis and mucinous tumours. |
| Databáze: | OpenAIRE |
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