Prime-boost vaccination with a fowlpox vector and an inactivated avian influenza vaccine is highly immunogenic in Pekin ducks challenged with Asian H5N1 HPAI
| Autor: | S. Van Borm, Michel Bublot, M. Duboeuf, Bénédicte Lambrecht, M. Steensels, S. Chanavat-Bizzini, J. De Vriese, F. X. le Gros, Alexandra Richard-Mazet, T. van den Berg |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Fowlpox
animal structures animal diseases Immunization Secondary Chick Embryo Biology medicine.disease_cause Antibodies Viral Microbiology Immune system Cloaca Immunity medicine Animals Mouth Vaccines Synthetic Fowlpox virus General Veterinary General Immunology and Microbiology Influenza A Virus H5N1 Subtype Immunogenicity Public Health Environmental and Occupational Health Hemagglutination Inhibition Tests medicine.disease Virology Influenza A virus subtype H5N1 Virus Shedding Vaccination Infectious Diseases Ducks Immunization Vaccines Inactivated Influenza Vaccines Influenza in Birds Inactivated vaccine Molecular Medicine Female |
| Zdroj: | Vaccine. 27(5) |
| ISSN: | 0264-410X |
| Popis: | The efficacy of different vaccination schedules was evaluated in 17-day-old Pekin ducks using an experimental inactivated whole virus vaccine based on the H5N9 A/chicken/Italy/22A/98 isolate (H5N9-It) and/or a fowlpox recombinant (vFP-H5) expressing a synthetic HA gene from an Asian H5N1 isolate (A/chicken/Indonesia/7/2003). Full protection against clinical signs and shedding was induced by the different vaccination schemes. However, the broadest antibody response and the lowest antibody increase after challenge were observed in the group of ducks whose immune system was primed with the fowlpox vectored vaccine and boosted with the inactivated vaccine, suggesting that this prime-boost strategy induced optimal immunity against H5N1 and minimal viral replication after challenge in ducks. In addition, this prime-boost vaccination scheme was shown to be immunogenic in 1-day-old ducklings. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect