The Effect of Ozone on Bone Strenght in Animal Model of Rheumatoid Arthritis
| Autor: | Mustafa Yilmaz, Buket Demirci, Gülcan Gürer, Gülnur Taşçi Bozbaş, Figen Sevil Kilimci |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
rheumatoid arthritis
0301 basic medicine medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Osteoporosis lcsh:Medicine Arthritis Gastroenterology 03 medical and health sciences Animal model Bone strength Freund’s complet adjuvan arthritis Internal medicine medicine Saline business.industry lcsh:R Normal population lcsh:Other systems of medicine lcsh:RZ201-999 medicine.disease Complete adjuvant ozone 030104 developmental biology Rheumatoid arthritis business |
| Zdroj: | Türk Osteoporoz Dergisi, Vol 22, Iss 2, Pp 74-79 (2016) |
| ISSN: | 2146-3816 |
| DOI: | 10.4274/tod.41736 |
| Popis: | Objective: Periarticular and systemic osteoporosis are more common in rheumatoid arthritis (RA) than normal population. In this study, we aimed to investigate the effectiveness of ozone on bone strength in Freund’s complete adjuvant (FCA) arthritis, which is considered as the animal model for RA. Materials and Methods: In this study, 28 male Wistar rats were used. Saline was injected into the hindpaws of 14 rats, and Freund’s complete adjuvant was injected into the hindpaws of the other 14 rats, subcutaneously. At the end of two weeks, 40 µg/ml ozone was administered intraperitoneally to 7 of the rats in each group for 6 times totally within duration of three weeks. At the 6th week, serum interleukin-1 (IL-1), IL-6 and tumor necrosis factor-alpha (TNF-α) levels were measured. Right femurs were separated for 3-point flexure test. Results: TNF-α levels of FCA arthritis were significantly higher than that of the control group (p0.05). Serum levels of IL-1 and IL-6 were not statistically significant among all groups (p>0.05). Maximum force and moment of inertia tended to increase in FCA arthritis-ozone group compare to the FCA arthritis group (p>0.05). The stiffness and toughness were similar in the all groups (p>0.05). Conclusion: To the best of our knowledge, this is the first study in which the effects of ozone on bone strength of RA were investigated. It is determined that ozone is not effective enough, but not harmful on bone strength of FCA arthritis. It is clear that further studies are required with ozone treatment and its use in RA when administrated in different doses and time courses. |
| Databáze: | OpenAIRE |
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