A new functional isoform of the human CRF2 receptor for corticotropin-releasing factor
| Autor: | Volker Breu, Olivier Valdenaire, J. Gottowik, Gavin J. Kilpatrick, Thomas Giller |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Gene isoform
endocrine system medicine.medical_specialty DNA Complementary Corticotropin-Releasing Hormone Sauvagine Peptide Hormones Molecular Sequence Data Biophysics Binding Competitive Receptors Corticotropin-Releasing Hormone Biochemistry Amphibian Proteins Cell Line Corticotropin-releasing hormone receptor 1 Growth factor receptor Structural Biology Internal medicine Genetics medicine Humans Amino Acid Sequence Cloning Molecular Receptor Urocortins Urocortin Base Sequence Chemistry Muscles Endocrinology Interleukin-21 receptor Peptides Sequence Alignment hormones hormone substitutes and hormone antagonists |
| Zdroj: | Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1352:129-132 |
| ISSN: | 0167-4781 |
| DOI: | 10.1016/s0167-4781(97)00047-x |
| Popis: | We have identified the human counterpart of the corticotropin-releasing factor receptor subtype 2beta. Its functional response to human urocortin was demonstrated after stable expression in HEK-293 cells. The receptor was also shown to bind sauvagine, corticotropin-releasing factor and urocortin. In contrast to rodents, the human CRF(2beta) receptor is only weakly expressed in heart and skeletal tissues, where the CRF(2alpha) isoform is predominant. Moreover, we have identified additional mRNAs of the CRF(2beta) type which are probably a consequence of aberrant splicing events. |
| Databáze: | OpenAIRE |
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