Significance of serum protein S100 levels in screening for melanoma metastasis: does protein S100 enable early detection of melanoma recurrence?
| Autor: | B. Schlagenhauff, B. Schittek, Andreas Blum, Claus Garbe, G. Rassner, Waltraud Stroebel, U. Ellwanger, M. Schwarz |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
Male Oncology Cancer Research medicine.medical_specialty Serum protein Early detection S100 Calcium Binding Protein beta Subunit Dermatology Disease Sensitivity and Specificity Metastasis Predictive Value of Tests Recurrence Reference Values Internal medicine Biomarkers Tumor Humans Medicine False Positive Reactions Nerve Growth Factors Neoplasm Metastasis Melanoma Neoplasm Staging Immunoradiometric assay business.industry Calcium-Binding Proteins S100 Proteins Reproducibility of Results medicine.disease Predictive value of tests Disease Progression Female Immunoradiometric Assay business |
| Zdroj: | Melanoma Research. 10:451-459 |
| ISSN: | 0960-8931 |
| DOI: | 10.1097/00008390-200010000-00007 |
| Popis: | A number of recent reports suggest serum protein S100 as a prognostic parameter in patients with metastatic melanoma. In the present study, serum protein S100 was investigated as a tumour marker for screening for melanoma metastasis in patients attending regular follow-up examinations. During the period from September 1997 to December 1998, serum protein S100 levels were measured by an immunoluminometric assay in 411 consecutive high risk melanoma patients (666 samples) and in 120 control subjects. Melanoma patients with resected primary tumours with a tumour thickness of 1.5 mm or more with resected metastasis were included in the study. Overall, 41 of the 411 patients developed metastasis during the period of observation. According to the distribution of protein S100 levels, the following different cut-off values were examined: 0.08 microg/l (95 percentile of the control group) and 0.13 microg/l (95 percentile of the group of melanoma patients without metastasis). The test efficiency for protein S100 as a diagnostic test for the detection of metastasis was highest for the cut-off value of 0.13 microg/l. In eight of the 41 patients (19.5%), elevation of protein S100 was the first sign of recurrence. Of the 41 patients with metastatic disease, 13 had elevated protein S100, giving a sensitivity of 0.32. The specificity for the detection of metastasis was 0.96. In eight of the 14 patients (57%) who developed distant metastasis, elevated S100 values were the first sign of tumour progression. In conclusion, determination of serum protein S100 levels enables earlier detection of distant metastasis in patients at high risk for metastasis. The impact on survival time needs to be investigated in follow-up studies. |
| Databáze: | OpenAIRE |
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