Experimental evaluation of anti-inflammatory, antinociceptive and antipyretic activities of clove oil in mice
| Autor: | Jamal S. Elmezogi, Fathy E El-Taher, Hanan A. Salem, Awatef M. Samud, Ghazala ben-Hussin, Badryia F. Al-Mehdawi, Yousef A. Taher |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
Antipyretics mice Fever Mice Inbred A medicine.drug_class Syzygium Analgesic Anti-Inflammatory Agents Pain lcsh:Medicine Eugenia caryophyllata clove oil eugenol antinociceptive anti-inflammatory antipyretic Anti-inflammatory chemistry.chemical_compound Animals Edema Medicine Antipyretic Hot plate test Pharmacology Analgesics Aspirin Traditional medicine biology business.industry Myrtaceae lcsh:R General Medicine biology.organism_classification Carrageenan Eugenol Disease Models Animal chemistry Anesthesia Original Article business medicine.drug |
| Zdroj: | Libyan Journal of Medicine, Vol 10, Iss 0, Pp 1-7 (2015) Libyan Journal of Medicine; Vol 10 (2015): incl Supplements Libyan Journal of Medicine; Vol 10, No 1 (2015) The Libyan Journal of Medicine |
| ISSN: | 1819-6357 1993-2820 |
| Popis: | Background: Clove oil of Eugenia caryophyllata (Myrtaceae) is a light yellowish fluid obtained from dried flower buds. Clove oil is used traditionally to relieve toothache.Aim: The aim of the present work was to study the anti-inflammatory, antinociceptive and antipyretic potential of clove oil in mice.Methods: Analgesic activity was examined using acetic-acid-induced abdominal constrictions and the hot plate test. Carrageenan-induced paw edema and brewer’s-yeast-induced pyrexia were used to investigate the anti-inflammatory activity and the antipyretic effects, respectively. The oil was administered intraperitoneally (i.p.) at a dose of 33 mg/kg body weight and the effects were compared with reference drugs.Results: In the antinociceptive test, mice treated with clove oil exhibited significantly decreased acetic-acid-induced writhing movements by a maximum of 87.7% (p |
| Databáze: | OpenAIRE |
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