Sustained hyperglycemia and insulin resistance induced by dietary restriction
| Autor: | Masao Miwa, Takayuki Kaihatsu, Toshio Maeda, Rieko Sakita |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty medicine.medical_treatment Pharmaceutical Science Impaired glucose tolerance Mice Insulin resistance Diabetes mellitus Internal medicine medicine Hyperinsulinemia Animals Hypoglycemic Agents Insulin Pancreatic hormone Pharmacology Glucose tolerance test medicine.diagnostic_test business.industry digestive oral and skin physiology General Medicine Fasting Glucose Tolerance Test medicine.disease Insulin oscillation Endocrinology Hyperglycemia Insulin Resistance business |
| Zdroj: | Biologicalpharmaceutical bulletin. 24(8) |
| ISSN: | 0918-6158 |
| Popis: | This investigation considered whether defects in insulin secretion and insulin action may result in the development of sustained hyperglycemia induced by refeeding standard chow pellets. Hyperglycemia, sustained for 36 h was induced, in mice that ate standard chow pellets ad libitum after 48 h fasting, but not 24 h fasting. In 48 h-fasted mice, serum insulin levels were remarkably low and the ability of insulin secretion to respond to glucose was decreased, although insulin-stimulated glucose disposal was not impaired. However, hyperinsulinemia was observed after refeeding for 12 h. The 12 h-refed mice had impaired glucose tolerance and were remarkably insulin resistant. These results suggest that hyperglycemia induced by the fasting-refeeding was caused by hyperphagia and the failure of insulin secretion, and maintained the resulting induced insulin resistance. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|