Combinatorial design of calcium meta phosphate poly(vinyl alcohol) bone-like biocomposites
| Autor: | Lilis Iskandar, Sanjukta Deb, N Gurav, Shathani Nkhwa |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Calcium Phosphates
Vinyl alcohol Materials science Biocompatibility Cell Survival Composite number Biomedical Engineering Biophysics chemistry.chemical_element Biocompatible Materials Bioengineering 02 engineering and technology Calcium Mechanics 010402 general chemistry Elastomer 01 natural sciences Cell Line Biomaterials chemistry.chemical_compound Brittleness Materials Testing Spectroscopy Fourier Transform Infrared medicine Humans Osteoblasts Temperature Water Hydrogels Special Issue: ESB 2017 021001 nanoscience & nanotechnology 0104 chemical sciences chemistry Polyvinyl Alcohol Bone Substitutes Self-healing hydrogels Microscopy Electrochemical Scanning Swelling medicine.symptom 0210 nano-technology Porosity Biomedical engineering |
| Zdroj: | Nkhwa, S, Iskandar, L, Gurav, N & Deb, S 2018, ' Combinatorial design of calcium meta phosphate poly(vinyl alcohol) bone-like biocomposites ', Journal of Materials Science: Materials in Medicine, vol. 29, no. 8, 128 . https://doi.org/10.1007/s10856-018-6133-6 Journal of Materials Science. Materials in Medicine |
| ISSN: | 1573-4838 0957-4530 |
| Popis: | The incidence of degenerative diseases and the ageing population have added to the growing demand for bone grafts. Although autologous bone continues to be the gold standard, limited yield and potential morbidity of the donor site pose considerable challenges. Currently, clinically used synthetic grafts based on calcium phosphates are mechanically brittle and not compliant hence composite scaffolds are expected to be provide viable solutions. In this study we report composites of calcium meta phosphate-poly (vinyl alcohol) with tunable mechanical properties, low swelling and excellent biocompatibility. The elastomeric nature of the composites resist brittle fracture and the scaffolds can be easily shaped to the bone defect by the surgeon. Testing on bone plug shaped specimens of the scaffolds, exhibited superior mechanical properties compared to currently commercially available bone plugs with additional advantages being the ability to increase porosity without compromising properties in compression and degree of swelling, which make these composites promising synthetic alternatives for bone grafts and bone tissue engineering. |
| Databáze: | OpenAIRE |
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