Early parent-child interactions and substance use disorder: An attachment perspective on a biopsychosocial entanglement
| Autor: | Leonardo Tadonio, Paolo Ossola, Pietro Pellegrini, Gilberto Gerra, Maria Lidia Gerra, Carlo Marchesi, Maria Carla Gerra, Elizabeth Mattfeld |
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| Rok vydání: | 2021 |
| Předmět: |
Biopsychosocial model
Hypothalamo-Hypophyseal System Substance-Related Disorders Cognitive Neuroscience media_common.quotation_subject Pituitary-Adrenal System Attachment Substance use Epigenesis Genetic Behavioral Neuroscience Genetic Monoaminergic Humans Medicine Early childhood Epigenetics Parent-Child Relations Endogenous opioid media_common business.industry Addiction Epigenetic medicine.disease Object Attachment Substance abuse Neuroendocrine Neuropsychology and Physiological Psychology Opioid Child Preschool business Clinical psychology medicine.drug |
| Zdroj: | Gerra, M L, Gerra, M C, Tadonio, L, Pellergini, P, Marchesi, C, Mattfeld, E, Gerra, G & Ossola, P 2021, ' Early parent-child interactions and substance use disorder : An attachment perspective on a biopsychosocial entanglement ', Neuroscience and Biobehavioral Reviews, vol. 131, pp. 560-580 . https://doi.org/10.1016/j.neubiorev.2021.09.052 |
| ISSN: | 0149-7634 |
| DOI: | 10.1016/j.neubiorev.2021.09.052 |
| Popis: | This review aims to elucidate environmental and genetic factors, as well as their epigenetic and neuroendocrine moderators, that may underlie the association between early childhood experiences and Substance Use Disorders (SUD), through the lens of parental attachment. Here we review those attachment-related studies that examined the monoaminergic systems, the hypothalamic pituitary adrenal stress response system, the oxytoninergic system, and the endogenous opioid system from a genetic, epigenetic, and neuroendocrine perspective. Overall, the selected studies point to a moderating effect of insecure attachment between genetic vulnerability and SUD, reasonably through epigenetic modifications. Preliminary evidence suggests that vulnerability to SUDs is related with hypo-methylation (e.g. hyper-expression) of high-risk polymorphisms on the monoaminergic and hypothalamic pituitary adrenal system and hyper-methylation (e.g. hypo-expressions) of protective polymorphisms on the opioid and oxytocin system. These epigenetic modifications may induce a cascade of neuroendocrine changes contributing to the subclinical and behavioural manifestations that precede the clinical onset of SUD. Protective and supportive parenting could hence represent a key therapeutic target to prevent addiction and moderate insecure attachment. |
| Databáze: | OpenAIRE |
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