Stress-induced brain activation: buffering role of social behavior and neuronal nicotinic receptors

Autor: Sylvie Granon, Anne Nosjean, Fabrice de Chaumont, Jean-Christophe Olivo-Marin
Přispěvatelé: Institut des Neurosciences Paris-Saclay (NeuroPSI), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Analyse d'images biologiques - Biological Image Analysis (BIA), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), This work was supported by the Centre National de la Recherche Scientifique (CNRS, UMR 9197), by the ANR-FLEXNEURIM and ANR-10-INBS-04 FranceBioImaging Grants. We thank Layla Veleanu for help with some behavioral and immunohistochemical experiments., ANR-09-BLAN-0340,FLEXNEURIM,Neurobiologie intégrative des comportements flexibles dans des modèles animaux par imagerie computationnelle : application en conditions normales et pathologiques(2009), ANR-10-INBS-0004,France-BioImaging,Développment d'une infrastructure française distribuée coordonnée(2010), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Male
c-fos
Histology
Genotype
Brain activity and meditation
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
Receptors
Nicotinic
Amygdala
c-Fos
Prefrontal cortex
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Corticosterone
medicine
Animals
Receptor
Social Behavior
Mice
Knockout
biology
[SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior
Kindling
General Neuroscience
[SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences
Social cognition
Mice
Inbred C57BL
Protein Subunits
030104 developmental biology
medicine.anatomical_structure
Nicotinic agonist
chemistry
nervous system
Nicotinic receptors
biology.protein
Anatomy
Neuroscience
Proto-Oncogene Proteins c-fos
030217 neurology & neurosurgery
Stress
Psychological
Zdroj: Brain Structure and Function
Brain Structure and Function, Springer Verlag, 2018, pp.1-16. ⟨10.1007/s00429-018-1745-7⟩
Brain Structure and Function, 2018, pp.1-16. ⟨10.1007/s00429-018-1745-7⟩
ISSN: 1863-2653
1863-2661
Popis: International audience; Social behavior and stress responses both rely on activity in the prefrontal cortex (PFC) and amygdala. We previously reported that acute stress exposure impoverishes social repertoire and triggers behavioral rigidity, and that both effects are modulated by β2-containing nicotinic receptors. We, therefore, hypothesized that the activity of brain regions associated with the integration of social cues will be modulated by stress exposure. We mapped the expression of c-fos protein in all subregions of the PFC and basolateral (BLA) and central (Ce) areas of the amygdala in C57BL/6J (B6) and β2-/- mice. We show altered brain activity and differences in functional connectivity between the two genotypes after stress: the PFC and BLA were hyperactivated in B6 and hypo-activated in β2-/- mice, showing that the impact of stress on brain activity and functional organization depends on the nicotinic system. We also show that the effects of the opportunity to explore a novel environment or interact socially after acute stress depended on genotype: exploration induced only marginal PFC activation in both genotypes relative to stress alone, excluding a major role for β2 receptors in this process. However, social interaction following stress only activated the rostral and caudolateral areas of the PFC in B6 mice, while it induced a kindling of activation in all PFC and amygdalar areas in β2-/- mice. These results indicate that acute stress triggers important PFC-amygdala plasticity, social interaction has a buffering role during stress-induced brain activation, and β2 receptors contribute to the effects of social interaction under stress.
Databáze: OpenAIRE
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