Stress-induced brain activation: buffering role of social behavior and neuronal nicotinic receptors
Autor: | Sylvie Granon, Anne Nosjean, Fabrice de Chaumont, Jean-Christophe Olivo-Marin |
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Přispěvatelé: | Institut des Neurosciences Paris-Saclay (NeuroPSI), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Analyse d'images biologiques - Biological Image Analysis (BIA), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), This work was supported by the Centre National de la Recherche Scientifique (CNRS, UMR 9197), by the ANR-FLEXNEURIM and ANR-10-INBS-04 FranceBioImaging Grants. We thank Layla Veleanu for help with some behavioral and immunohistochemical experiments., ANR-09-BLAN-0340,FLEXNEURIM,Neurobiologie intégrative des comportements flexibles dans des modèles animaux par imagerie computationnelle : application en conditions normales et pathologiques(2009), ANR-10-INBS-0004,France-BioImaging,Développment d'une infrastructure française distribuée coordonnée(2010), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS) |
Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Male c-fos Histology Genotype Brain activity and meditation [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology Receptors Nicotinic Amygdala c-Fos Prefrontal cortex 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Corticosterone medicine Animals Receptor Social Behavior Mice Knockout biology [SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior Kindling General Neuroscience [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences Social cognition Mice Inbred C57BL Protein Subunits 030104 developmental biology medicine.anatomical_structure Nicotinic agonist chemistry nervous system Nicotinic receptors biology.protein Anatomy Neuroscience Proto-Oncogene Proteins c-fos 030217 neurology & neurosurgery Stress Psychological |
Zdroj: | Brain Structure and Function Brain Structure and Function, Springer Verlag, 2018, pp.1-16. ⟨10.1007/s00429-018-1745-7⟩ Brain Structure and Function, 2018, pp.1-16. ⟨10.1007/s00429-018-1745-7⟩ |
ISSN: | 1863-2653 1863-2661 |
Popis: | International audience; Social behavior and stress responses both rely on activity in the prefrontal cortex (PFC) and amygdala. We previously reported that acute stress exposure impoverishes social repertoire and triggers behavioral rigidity, and that both effects are modulated by β2-containing nicotinic receptors. We, therefore, hypothesized that the activity of brain regions associated with the integration of social cues will be modulated by stress exposure. We mapped the expression of c-fos protein in all subregions of the PFC and basolateral (BLA) and central (Ce) areas of the amygdala in C57BL/6J (B6) and β2-/- mice. We show altered brain activity and differences in functional connectivity between the two genotypes after stress: the PFC and BLA were hyperactivated in B6 and hypo-activated in β2-/- mice, showing that the impact of stress on brain activity and functional organization depends on the nicotinic system. We also show that the effects of the opportunity to explore a novel environment or interact socially after acute stress depended on genotype: exploration induced only marginal PFC activation in both genotypes relative to stress alone, excluding a major role for β2 receptors in this process. However, social interaction following stress only activated the rostral and caudolateral areas of the PFC in B6 mice, while it induced a kindling of activation in all PFC and amygdalar areas in β2-/- mice. These results indicate that acute stress triggers important PFC-amygdala plasticity, social interaction has a buffering role during stress-induced brain activation, and β2 receptors contribute to the effects of social interaction under stress. |
Databáze: | OpenAIRE |
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