Serum Cystatin C as a Potential Marker for Glomerular Filtration Rate in Patients with Cholangiocarcinoma
| Autor: | Mang Ngaih Ciin, Tanakorn Proungvitaya, Temduang Limpaiboon, Sittiruk Roytrakul, Ubon Cha’on, Doungdean Tummanatsakun, Siriporn Proungvitaya |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
030232 urology & nephrology Renal function urologic and male genital diseases lcsh:RC254-282 Gastroenterology Cholangiocarcinoma 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Chronic kidney disease epidemiology collaboration (CKD-EPI) equation Serum cystatin Internal medicine parasitic diseases medicine In patient Cystatin C Stage (cooking) reproductive and urinary physiology Transplantation Creatinine biology business.industry Cancer Hematology lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease female genital diseases and pregnancy complications CKD-EPI equation Glomerular filtration rate Oncology chemistry 030220 oncology & carcinogenesis biology.protein Original Article Glomerular filtration rate business Kidney disease |
| Zdroj: | International Journal of Hematology-Oncology and Stem Cell Research Scopus-Elsevier International Journal of Hematology-Oncology and Stem Cell Research, Vol 14, Iss 3 (2020) |
| ISSN: | 2008-2207 |
| DOI: | 10.18502/ijhoscr.v14i3.3723 |
| Popis: | Background: Cholangiocarcinoma (CCA) is the second most common primary hepatobiliary cancer. These patients have meager prognosis and short-term survival. Precise assessment of glomerular filtration rate is a fundamental aspect of clinical care in cancer patients. Cystatin C has been proposed to be superior to creatinine, a well-known marker of renal function. This study aimed to evaluate cystatin C as a marker of GFR calculation in CCA patients. Materials and Methods: One hundred thirty serum samples from CCA patients and 32 from controls were included in this study. Serum cystatin C was measured using immunoturbidity assay. Estimated glomerular filtration rate was calculated by three equations established by chronic kidney disease epidemiology collaboration (based on creatinine and/or cystatin C). Results: Serum cystatin C in CCA patients was higher than that of controls (p=0.0002). Cystatin C was positively correlated with BUN in CCA group (p=0.019). eGFR based on cystatin C and based on both cystatin C and creatinine in CCA was low with significantly different from those of control (p |
| Databáze: | OpenAIRE |
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