Spatial Delivery of Triple Functional Nanoparticles via an Extracellular Matrix-Mimicking Coaxial Scaffold Synergistically Enhancing Bone Regeneration

Autor:	Danlei Xing, Wei Zuo, Jiahong Chen, Buyun Ma, Xi Cheng, Xuefeng Zhou, Yunzhu Qian
Rok vydání:	2022
Předmět:	Mice Bone Regeneration Tissue Engineering Tissue Scaffolds Osteogenesis Animals Nanoparticles General Materials Science Zinc Oxide Anti-Bacterial Agents Extracellular Matrix Rats
Zdroj:	ACS Applied Materials & Interfaces. 14:37380-37395
ISSN:	1944-8252 1944-8244
DOI:	10.1021/acsami.2c08784
Popis:	It remains a major challenge to simultaneously achieve bone regeneration and prevent infection in the complex microenvironment of repairing bone defects. Here, we developed a novel ECM-mimicking scaffold by coaxial electrospinning to be endowed with multibiological functions. Lysophosphatidic acid (LPA) and zinc oxide (ZnO) nanoparticles were loaded into the poly-lactic
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03da4fcad0da6d2402d548673ad6ec54 https://doi.org/10.1021/acsami.2c08784 Zobrazit plný text záznamu