Comparing reduced-dose sodium phosphate tablets to 2 L of polyethylene glycol: A randomized study
| Autor: | Soichiro Ako, H. Tsugeno, Yuki Baba, Mayu Murakami, Hamada Kenta, Ryuta Takenaka, Sakiko Hiraoka, Daisuke Kawai, Eriko Yasutomi, Jun Kato, Shohei Oka, Chihiro Sakaguchi, Tomoko Sunami, Koji Takemoto, Shigeatsu Fujiki, Toshiyuki Asato, Noriko Okazaki, Yasushi Yamasaki |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Polyethylene glycol Sodium chemistry.chemical_element Colonoscopy Cathartic Administration Oral Pharmacology law.invention Phosphates Polyethylene Glycols 03 medical and health sciences chemistry.chemical_compound Young Adult 0302 clinical medicine Sex Factors Randomized controlled trial law Surveys and Questionnaires Medicine Humans Prospective Studies Prospective cohort study medicine.diagnostic_test business.industry Cathartics technology industry and agriculture Gastroenterology Age Factors General Medicine Middle Aged Phosphate Reduced dose Treatment Outcome chemistry 030220 oncology & carcinogenesis Randomized Clinical Trial Preparation Sodium phosphate tablets 030211 gastroenterology & hepatology Female business Colorectal Neoplasms Tablets |
| Zdroj: | World Journal of Gastroenterology |
| ISSN: | 2219-2840 |
| Popis: | AIM To compare the tolerability and quality of bowel cleansing between 2 L polyethylene glycol (PEG) and reduced-dose sodium phosphate (NaP) tablets as a preparation for colonoscopy. METHODS Two hundred patients were randomly assigned to the PEG or NaP groups at the same ratio. The NaP group patients took 30 tablets with 2 L of clear liquid, while the PEG group patients took 2L of PEG. Tolerability was assessed by a questionnaire about taste, volume, and the overall impression. The bowel cleansing quality was evaluated by colonoscopists. RESULTS Although NaP showed better tolerability in terms of taste, volume and overall impression (P < 0.01, P < 0.01 and P = 0.02, respectively), the overall cleansing quality was better in the PEG group (P < 0.01). A subgroup analysis, stratified by sex and age, indicated that NaP was associated with better tolerability and equivalent bowel cleansing quality in females of < 50 years of age. CONCLUSION Despite the better tolerability, the use of 30 NaP tablets with 2 L of clear liquid should be limited due to its lower cleansing quality; however, in certain cases the regimen may deserve consideration, particularly in cases involving young women. |
| Databáze: | OpenAIRE |
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