Structural brain alterations in subjects at high-risk of psychosis: A voxel-based morphometric study
| Autor: | H.-J. Möller, Ronald Bottlender, Maximilian F. Reiser, E. M. Meisenzahl, Bernhard Burgermeister, Philip McGuire, Petra Decker, G. J. E. Schmitt, Christian Gaser, Christoph Born, Nikolaos Koutsouleris |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty Psychosis Cross-sectional study Early detection Grey matter computer.software_genre Risk Factors Voxel Internal medicine Healthy control Image Processing Computer-Assisted medicine Humans Psychiatry Biological Psychiatry Brain Neurodegenerative Diseases Voxel-based morphometry medicine.disease Control Groups Magnetic Resonance Imaging Temporal Lobe Frontal Lobe Psychiatry and Mental health Cross-Sectional Studies medicine.anatomical_structure Temporal Regions Schizophrenia Female Atrophy Psychology computer Follow-Up Studies |
| Zdroj: | Schizophrenia Research. 102:150-162 |
| ISSN: | 0920-9964 |
| DOI: | 10.1016/j.schres.2008.02.023 |
| Popis: | Forty Untreated high-risk (HR) individuals for psychosis and 75 healthy control subjects (HC) matched for age, gender, handedness and educational level were investigated by structural MRI. HR subjects were recruited at the Early Detection and Intervention Centre for Mental Crises (FETZ) of the Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Germany. Measurements of gray matter volumes were performed by voxel-based morphometry using SPM5. The sample of HR subjects showed GM volume reductions in frontal, lateral temporal and medial temporal regions compared to the healthy control group. These regions are compatible with structural findings in the clinically apparent disease of schizophrenia. |
| Databáze: | OpenAIRE |
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