The relationship of 3-PBA pyrethroids metabolite and male reproductive hormones among non-occupational exposure males
| Autor: | Yan Han, Yankai Xia, Jiayuan Han, Ling Song, Nianzu Jin, Rencheng Zhao, Xinru Wang, Pengfei Zhu, Jinping Zhou, Shoulin Wang |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Insecticides Environmental Engineering Health Toxicology and Mutagenesis Urine Biology Benzoates Follicle-stimulating hormone Internal medicine parasitic diseases Pyrethrins medicine Environmental Chemistry Humans Occupations Gonadal Steroid Hormones Life Style Testosterone Public Health Environmental and Occupational Health Pesticide Residues General Medicine General Chemistry Environmental exposure Environmental Exposure Creatine Pollution Prolactin Endocrinology Endocrine disruptor Luteinizing hormone Hormone |
| Zdroj: | Chemosphere. 72(5) |
| ISSN: | 0045-6535 |
| Popis: | Many pesticides possess hormonal activities and have been classified as endocrine disrupting chemicals. Synthetic pyrethroids are one kind of the most common pesticides used in the world. In the present study, we explored the association between serum reproductive hormone levels and urinary creatine (CR) adjusted concentration of 3-phenoxybenzoic acid (3-PBA), a general metabolite of pyrethroids, in Chinese adult men. The study subjects (n=212) were from the affiliated hospitals of Nanjing Medical University. By using GC-MS, urinary 3-PBA level of each subject was measured and adjusted by urinary CR. Blood samples were collected for measuring the serum levels of reproductive hormones, including follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), testosterone (T) and prolactin (PRL). All the subjects had detectable levels of 3-PBA in their urine samples. The median concentration of 3-PBA was 0.815 microg g (-1)of CR. The results showed that there was positive associations between the levels of serum LH and 3-PBA (p=0.013) but negative associations between E2 and 3-PBA level (p=0.022), and the adjusting p-value was 0.044 for LH and E2, which suggested that pyrethroids are capable of disrupting the male endocrine function. In adult men, urinary 3-PBA levels were associated with increased LH and reduced E2 levels. On a population level, these reductions show potential public health importance because of widespread exposure to these pesticides. |
| Databáze: | OpenAIRE |
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