Representation and transformation of sensory information in the mouse accessory olfactory system
| Autor: | Hannah A. Arnson, Timothy E. Holy, Julian P. Meeks |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Olfactory system
Male sulfated steroids Vomeronasal organ Sensory Receptor Cells Models Neurological Action Potentials Sensory system Biology mitral cells In Vitro Techniques Urine sensory coding Article 03 medical and health sciences Mice 0302 clinical medicine vomeronasal neurons Physical Stimulation Animals Cluster Analysis 030304 developmental biology 0303 health sciences Estradiol Sulfates General Neuroscience accessory olfactory bulb Dendrites Social cue Olfactory Perception Olfactory Bulb Olfactory bulb Social Perception Estradiol sulfate Excitatory postsynaptic potential Linear Models Steroids Cues Vomeronasal Organ Neuroscience accessory olfactory system Microelectrodes 030217 neurology & neurosurgery |
| Zdroj: | Nature neuroscience |
| ISSN: | 1546-1726 1097-6256 |
| Popis: | In mice, nonvolatile social cues are detected and analyzed by the accessory olfactory system (AOS). Here we provide a first view of information processing in the AOS with respect to individual chemical cues. 12 sulfated steroids, recently discovered mouse AOS ligands, caused widespread activity among vomeronasal sensory neurons (VSNs), yet VSN responses clustered into a small number of repeated functional patterns or processing streams. Downstream neurons in the accessory olfactory bulb (AOB) responded to these ligands with enhanced signal/noise compared to VSNs. Although the dendritic connectivity of AOB mitral cells suggests the capacity for broad integration, most sulfated steroid responses were well-modeled by linear excitatory drive from just one VSN processing stream. However, a substantial minority demonstrated multi-stream integration. Most VSN excitation patterns were also observed in the AOB, but excitation by estradiol sulfate processing streams was rare, suggesting AOB circuit organization is specific to the biological relevance of sensed cues. |
| Databáze: | OpenAIRE |
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