Characteristics of severe asthma with fungal sensitization
| Autor: | Rie Baba, Akira Umeda, Masako Matsusaka, Yusuke Suzuki, Takae Tanosaki, Kenji Izuhara, Kengo Ohtsuka, Katsuhiko Kamei, Morio Nakamura, Tomoko Betsuyaku, Hiroki Kabata, Takashi Inoue, Takao Mochimaru, Soichiro Ueda, Koichiro Asano, Katsunori Masaki, Koichi Fukunaga, Hidefumi Koh, Takashi Kamatani, Fumio Sakamaki, Tsuyoshi Oguma, Koichi Sayama, Yoshitaka Oyamada |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine Pulmonary and Respiratory Medicine Antigens Fungal Immunology Nitric Oxide Immunoglobulin E medicine.disease_cause Severity of Illness Index Pulmonary function testing Young Adult 03 medical and health sciences 0302 clinical medicine Allergen Forced Expiratory Volume Humans Immunology and Allergy Medicine Trichophyton Sensitization Aged Asthma Aged 80 and over biology business.industry Fungi Allergens Middle Aged biology.organism_classification Alternaria medicine.disease 030104 developmental biology medicine.anatomical_structure 030228 respiratory system Exhaled nitric oxide biology.protein Cytokines Female business |
| Zdroj: | Annals of Allergy, Asthma & Immunology. 119:253-257 |
| ISSN: | 1081-1206 |
| DOI: | 10.1016/j.anai.2017.07.008 |
| Popis: | Some patients with severe asthma also have fungal sensitization and are considered to have severe asthma with fungal sensitization. However, there is limited information on the clinical features of SAFS.To investigate the clinical characteristics of severe asthma with fungal sensitization.The present study enrolled 124 patients with severe asthma. We evaluated clinical aspects, such as various serum cytokines, fractional exhaled nitric oxide, pulmonary function, and serum immunoglobulin E (IgE). Fungal sensitization was assessed by determining serum levels of IgE specific to fungal allergens (Aspergillus, Alternaria, Candida, Cladosporium, Penicillium, and Trichophyton species and Schizophyllum commune). The protocol was registered at a clinical trial registry (www.umin.ac.jp/ctr/index-j.htm; UMIN 000002980).Thirty-six patients (29%) showed sensitization to at least 1 fungal allergen. The most common species were Candida (16%), Aspergillus (11%), and Trichophyton (11%). The rate of early-onset asthma (16 years of age) was higher in patients with fungal sensitization than in those without fungal sensitization (45% vs 25%; P = .02). Interleukin-33 levels were higher in patients with fungal sensitization than in those without fungal sensitization. Of patients with atopic asthma, Asthma Control Test scores were worse in patients with multiple fungal sensitizations than in patients with a single fungal sensitization or those without fungal sensitization.Severe asthma with fungal sensitization is characterized by early onset of disease and high serum levels of interleukin-33. Multiple fungal sensitizations are associated with poor asthma control.UMIN Clinical Trials Registry (UMIN-CTR; www.umin.ac.jp/ctr/index-j.htm): UMIN 000002980. |
| Databáze: | OpenAIRE |
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