Elevated Systemic L-Kynurenine/L-Tryptophan Ratio and Increased IL-1 Beta and Chemokine (CX3CL1, MCP-1) Proinflammatory Mediators in Patients with Long-Term Titanium Dental Implants
| Autor: | Adolfo Toledano Gasca, Juana Benedí, José María Parmigiani-Izquierdo, Fabio Camacho-Alonso, María Eugenia Cabaña-Muñoz, Alba Garcimartín, José Joaquín Merino |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Chemokine
medicine.medical_specialty medicine.medical_treatment Farmacología lcsh:Medicine engineering.material Article IDO Proinflammatory cytokine 03 medical and health sciences 0302 clinical medicine stomatognathic system Tryptophan (L-Trp) Internal medicine CX3CR1 Medicine Titanium dental implants and dental amalgam fillings L-Kyn/L-Trp CX3CL1 Melatonin 030304 developmental biology Inflammation 0303 health sciences CX3CL1 (fractalkine) biology business.industry Chemotaxis Monocyte lcsh:R technology industry and agriculture Interleukin General Medicine His Amalgam (dentistry) stomatognathic diseases Endocrinology Cytokine medicine.anatomical_structure Kynurenine pathways tryptophan (L-Trp) cytokines biology.protein engineering Amino acids Cytokines Dentistry and medical toxicology Chemokines business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Clinical Medicine E-Prints Complutense. Archivo Institucional de la UCM instname Digital.CSIC. Repositorio Institucional del CSIC Volume 8 Issue 9 E-Prints Complutense: Archivo Institucional de la UCM Universidad Complutense de Madrid Journal of Clinical Medicine, Vol 8, Iss 9, p 1368 (2019) |
| Popis: | Titanium is the mean biocompatible metal found in dental titanium alloys (Ti-6Al-4V). The safety of certain dental biomaterial amalgams has been questioned in patients. The levels of several systemic cytokines (interleukin (IL)-1 beta, IL-4: pg/mL) and chemokines (monocyte chemoattractant protein-1 (MCP-1), soluble fractalkine (CX3CL1: pg/mL) were determined using ELISA and compared between these study groups. The study included 30 controls without dental materials (cont), 57 patients with long-term titanium dental implants plus amalgams (A + I group) as well as 55 patients with long-term dental amalgam alone (A group). All patients (except controls) have had dental titanium implants (Ti-6Al-4V) and/or amalgams for at least 10 years (average: 15 years). We evaluated whether systemic levels of cytokines/chemokines, kyn/L-trp ratio and aromatic amino acid levels (HPLC: mM/L, Phe, L-Trp, His, Treo) could be altered in patients with long-term dental titanium and/or amalgams. These systemic markers were evaluated in 142 patients. The A + I group had higher L-Kynurenine/L-Tryptophan ratios than patients with long-term dental amalgam fillings alone (A). In addition, levels of IL-1 Beta cytokine, CX3CL1 and MCP-1 chemokines were higher in the A + I group than in the A group (A). The increased L-kyn/L-trp ratio and MCP-1 and fractalkine receptor (CX3CR1) elevations could suggest enhanced chemotactic responses by these chemokines in the A + I group. |
| Databáze: | OpenAIRE |
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