Rifampicin-Resistant Tuberculosis in a Toddler: A Report of a Rare Paediatric Case in Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria

Autor: S S Edward, P O Obiajunwa, J I Akande
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Nigerian Medical Journal : Journal of the Nigeria Medical Association
Nigerian Medical Journal; Vol. 61 No. 5 (2020); 281-283
ISSN: 2229-774X
0300-1652
Popis: The emergence of resistant strains of mycobacterium tuberculosis (TB) to antituberculous drugs has compounded the management of the chronic infection. More than 90% of rifampicin (RIF)‑resistant isolates are also isoniazid resistant; hence, rifampicin resistance (RR) is a surrogate marker for multidrug resistant TB (MDR‑TB). Although there are limited reports of pediatric RR/MDR‑TB in Nigeria, there had not been similar report in our hospital until now. A 2‑year‑old girl was admitted with 2‑month history of fever, cough with dyspnea, and progressive weight loss. There was no known contact with adult who had chronic cough; the toddler and her parents have not been treated for TB in the past. Her chest X‑ray showed nodular opacities, while gastric washout for GeneXpert MTB/RIF confirmed RIF‑resistant TB. The parents declined screening for TB despite counseling. The patient was subsequently referred to a specialized center for the management of drug‑resistant TB, but the parents failed to go for the treatment. Young children are at risk of developing TB disease and MDR/RR‑TB, which is more complex to manage than drug‑susceptible TB due to longer treatment duration, increased toxicity, as well as poor parental compliance to the demand of treatment.
Databáze: OpenAIRE
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