Inactivated influenza vaccine effectiveness and an analysis of repeated vaccination for children during the 2016/17 season
| Autor: | Takeshi Munenaga, Mitsuhiro Nishida, Norio Sugaya, Anna Goto, Masayoshi Shinjoh, Isamu Kamimaki, Atsushi Narabayashi, Yoshio Yamaguchi, Yasuaki Kobayashi, Kumiko Morita, Yasuhiro Hirano, Takao Takahashi, Satoshi Tamaoka, Yuji Nakata, Meiwa Shibata, Hisato Kobayashi, Keiko Mitamura, Noriko Iibuchi |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Pediatrics medicine.medical_specialty Adolescent Influenza vaccine 030106 microbiology 03 medical and health sciences 0302 clinical medicine Immunity Influenza Human Odds Ratio medicine Humans 030212 general & internal medicine Child Rapid diagnostic test General Veterinary General Immunology and Microbiology business.industry Influenza A Virus H3N2 Subtype Vaccination Public Health Environmental and Occupational Health Case-control study Infant Influenza a Odds ratio Hospitalization Influenza B virus Infectious Diseases Vaccines Inactivated Immunization Influenza Vaccines Case-Control Studies Child Preschool Molecular Medicine Female Seasons business |
| Zdroj: | Vaccine. 36:5510-5518 |
| ISSN: | 0264-410X |
| Popis: | Objectives We assessed the vaccine effectiveness (VE) of inactivated influenza vaccine (IIV) in children 6 months to 15 years of age during the 2016/17 season. In addition, we estimated the impact of repeated vaccination in children on VE. Methods Our study for VEs in preventing influenza and admission due to influenza were conducted according to a test-negative case-control design (TNCC) based on influenza rapid diagnostic test results. We also analyzed the VE by vaccine status in the current and previous seasons for the impact of repeated vaccination. Results During the 2016/17 season, the quadrivalent IIV was used in Japan. The adjusted VE in preventing influenza illness was 38% (95% CI, 29–46) against influenza A and 39% (95% CI, 18–54) against influenza B. Infants showed no significant VE. The VE in preventing hospitalization was not demonstrated. For the analysis of repeated vaccination, the vaccine was effective only when immunization occurred in the current season. The children who were immunized in two consecutive seasons were more likely to develop influenza compared to those immunized in the current season only (odds ratio, 1.58 [95% CI, 1.05–2.38], adjusted odds ratio, 1.53 [95% CI, 0.99–2.35]). However, the odds ratio of repeated vaccination was not significant when the analysis excluded those who developed influenza in the previous season. Conclusions VE in children in the 2016/17 season was similar to values previously reported. Repeated vaccination interfered with the VE against any influenza infection in the 2016/17 season. The results of our study suggest that decreased VE by repeat vaccination phenomenon was associated with immunity by influenza infection in the previous season. However, the influenza vaccine should be recommended every season for children. |
| Databáze: | OpenAIRE |
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