Synthesis and study of conformationally restricted 3'-deoxy-3',4'-exo-methylene nucleoside analogues
| Autor: | Gilles Gosselin, Julien Gagneron, Christophe Mathé |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Hepatitis B virus
Pyrimidine Stereochemistry Anti-HIV Agents Human immunodeficiency virus (HIV) HIV Infections macromolecular substances In Vitro Techniques medicine.disease_cause Virus Replication Biochemistry Antiviral Agents chemistry.chemical_compound Genetics medicine RNA Viruses Methylene RNA HIV Nucleosides General Medicine Hepatitis B Hydrocarbons chemistry Models Chemical Nucleic acid Molecular Medicine Nucleic Acid Conformation Nucleoside Methane |
| Zdroj: | Nucleosides, nucleotidesnucleic acids. 24(5-7) |
| ISSN: | 1525-7770 |
| Popis: | Hitherto unknown restricted 3'-deoxy-3',4'-exo-methylene nucleoside derivatives bearing the nucleic acid naturally occurring pyrimidine bases have been synthesized. The compounds were tested for their activity against HIV, HBV, and several RNA viruses, but they did not show significant antiviral effect. |
| Databáze: | OpenAIRE |
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