Nonalcoholic Fatty Liver Disease and Thrombocytopenia III: Its Association With Insulin Resistance
| Autor: | Iván Murrieta-Álvarez, Jesús Mauricio Olivares-Gazca, Antonio Cruz-Mora, Juan Carlos Olivares-Gazca, Guillermo J. Ruiz-Delgado, Yahveth Cantero-Fortiz, Andrés Aurelio León-Peña, Miguel Antonio López-Trujillo, Guillermo J. Ruiz-Argüelles, Yarely Itzayana García-Navarrete |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty lcsh:Diseases of the circulatory (Cardiovascular) system thrombocytopenia liver digestive system Young Adult 03 medical and health sciences 0302 clinical medicine Insulin resistance Non-alcoholic Fatty Liver Disease NAFLD insulin resistance Internal medicine hemic and lymphatic diseases Nonalcoholic fatty liver disease medicine Humans Platelet Prospective Studies Aged business.industry nutritional and metabolic diseases Hematology General Medicine Middle Aged medicine.disease digestive system diseases Endocrinology lcsh:RC666-701 030220 oncology & carcinogenesis platelets Female Original Article 030211 gastroenterology & hepatology business |
| Zdroj: | Clinical and Applied Thrombosis/Hemostasis, Vol 25 (2019) Clinical and Applied Thrombosis/Hemostasis |
| ISSN: | 1938-2723 |
| Popis: | Thrombocytopenia (less than 100 × 109/L platelets) presents in around one quarter of patients with nonalcoholic fatty liver disease (NAFLD), the hepatic component of insulin resistance (IR). It is unknown whether IR, by itself, associates with thrombocytopenia. Persons with NAFLD and/or IR were prospectively accrued in the study after February 2018. Insulin resistance was defined by assessing α hydroxybutyrate, lynoleoyl glycerolphosphocoline, oleic acid, and insulin (Quantose IR), whereas the presence of NAFLD was defined by serologic determinations (Fibromax) and liver transient elastography (Fibroscan). In 78 patients with NAFLD, thrombocytopenia was identified in 22 (28%), whereas in 19 persons with IR, 14 (73%) were found to have NAFLD. In persons with IR + NAFLD, thrombocytopenia presented in 9 (64%). In the subset of patients with IR, the prevalence of thrombocytopenia was 52%. There was only 1 patient with IR/without NAFLD who displayed thrombocytopenia. Significant statistical association between NAFLD and thrombocytopenia was found (odds ratio [OR]: = 13, confidence interval [CI]: 1.5-162, P = .05), whereas there was no association between IR and thrombocytopenia (OR = 0.38, CI: 0.06-2.3, P = .61). Insulin resistance, by itself, was not found to be associated with diminished platelet counts. The presence of NAFLD, one of the consequences of IR, seems to be required to lead into thrombocytopenia. |
| Databáze: | OpenAIRE |
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