Sleep quality in patients with primary aldosteronism
| Autor: | F. Hanusch, Bruno Allolio, Felix Beuschlein, Martin Reincke, Marcus Quinkler, Evelyn Fischer, Sven Diederich, Stephan Endres, Katharina Lang |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Sleep Wake Disorders Pediatrics medicine.medical_specialty medicine.medical_treatment Endocrinology Diabetes and Metabolism Blood Pressure Young Adult chemistry.chemical_compound Sex Factors Endocrinology Mineralocorticoid receptor Primary aldosteronism Quality of life Surveys and Questionnaires Internal medicine Hyperaldosteronism Internal Medicine medicine Humans Prospective Studies Registries Prospective cohort study Antihypertensive Agents Aged Aged 80 and over Aldosterone business.industry Adrenalectomy Epworth Sleepiness Scale Sleep apnea General Medicine Middle Aged medicine.disease Treatment Outcome Blood pressure chemistry Cohort Quality of Life Physical therapy Female Sleep business |
| Zdroj: | Hormones. 13:57-64 |
| ISSN: | 2520-8721 1109-3099 |
| Popis: | In subjects at high risk for sleep apnea (SA), aldosterone concentrations correlate with severity of SA and primary aldosteronism (PA) is very often diagnosed. Patients with PA show a high prevalence of SA. Treatment of PA either by adrenalectomy (ADX) or mineralocorticoid receptor (MR) blockade is thought to abolish the increased comorbidities. However, no data are available regarding effectiveness of different PA treatments on quality of sleep.This prospective multi-center study included 15 patients with newly diagnosed PA evaluated before and 0.7 ± 0.2 years after treatment initiation, and a second cohort including 81 patients who were evaluated 5.3 and 6.8 years after treatment initiation. Biochemical parameters, 24h blood pressure and three validated self-assessment questionnaires (Giessen Complaint List (GBB-24), Epworth Sleepiness Scale (ESS) and Pittsburgh Sleep Quality-Index (PSQI)) were analyzed.Z-scores of exhaustion tendency of GBB significantly improved in newly diagnosed PA patients after treatment initiation (1.8 ± 1.4 vs. 1.0 ± 1.2, p=0.034). In the second cohort no differences were found in GBB-24, ESS and PSQI. No differences were found in all three questionnaires independently of type of PA therapy. However, female patients scored significantly higher than males in the PSQI (8.7 ± 3.6 vs 5.7 ± 4.2, p0.005), indicating lower sleep quality, independently of the type of therapy.For the first time, we analyzed quality of sleep in patients with PA, demonstrating that therapy initiation improves exhaustion tendency. Surprisingly, female PA patients showed significantly more sleep disturbances than male PA patients several years after treatment initiation. |
| Databáze: | OpenAIRE |
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