GeneTrail 3: advanced high-throughput enrichment analysis
Autor: | Hans-Peter Lenhof, Carolin Mayer, Nico Gerstner, Kerstin Lenhof, Anne Müller, Martin Hart, Eckart Meese, Tony Wyss-Coray, Tim Kehl, Jörn Walter, Caroline Diener, Lea Eckhart, Nadja Grammes, Oliver Hahn, Andreas Keller |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
CD4-Positive T-Lymphocytes
Epigenomics Proteomics Aging AcademicSubjects/SCI00010 Genomic data education Computational biology Biology computer.software_genre Lymphocyte Activation 03 medical and health sciences Mice 0302 clinical medicine Genetics Animals Humans Throughput (business) 030304 developmental biology 0303 health sciences Gene Expression Profiling Genomics Visualization Identification (information) Workflow 030220 oncology & carcinogenesis Web Server Issue Lymphocyte activation Microglia Web service Single-Cell Analysis computer Software Network analysis Signal Transduction |
Zdroj: | Nucleic Acids Research |
ISSN: | 1362-4962 0305-1048 |
Popis: | We present GeneTrail 3, a major extension of our web service GeneTrail that offers rich functionality for the identification, analysis, and visualization of deregulated biological processes. Our web service provides a comprehensive collection of biological processes and signaling pathways for 12 model organisms that can be analyzed with a powerful framework for enrichment and network analysis of transcriptomic, miRNomic, proteomic, and genomic data sets. Moreover, GeneTrail offers novel workflows for the analysis of epigenetic marks, time series experiments, and single cell data. We demonstrate the capabilities of our web service in two case-studies, which highlight that GeneTrail is well equipped for uncovering complex molecular mechanisms. GeneTrail is freely accessible at: http://genetrail.bioinf.uni-sb.de. |
Databáze: | OpenAIRE |
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