Oxidative status of maternal blood in pregnancies burdened by inherited thrombophilias

Autor: Dragana Maglić, Miloš Opačić, Željko Miković, Ivan Spasojevic, Vesna Mandic, Milica Bajcetic, Jelena Bogdanović Pristov
Rok vydání: 2020
Předmět:
0301 basic medicine
Erythrocytes
Physiology
Maternal Health
Glutathione reductase
Blood Pressure
030204 cardiovascular system & hematology
medicine.disease_cause
Vascular Medicine
Biochemistry
Cohort Studies
0302 clinical medicine
Pregnancy
Animal Cells
Red Blood Cells
Blood plasma
Medicine and Health Sciences
Thrombophilia
Multidisciplinary
biology
Obstetrics and Gynecology
Body Fluids
Enzymes
3. Good health
Blood
Dismutases
Catalase
Hypertension
Medicine
Female
Cellular Types
Anatomy
Oxidoreductases
Oxidation-Reduction
Research Article
Adult
Science
Oxidative phosphorylation
Blood Plasma
Superoxide dismutase
03 medical and health sciences
Hypertensive Disorders in Pregnancy
Genetics
medicine
Humans
Glutathione Peroxidase
Blood Cells
Superoxide Dismutase
business.industry
Pregnancy Complications
Hematologic
Biology and Life Sciences
Proteins
Cell Biology
medicine.disease
Oxidative Stress
030104 developmental biology
Mutation
Enzymology
biology.protein
Women's Health
business
Oxidative stress
Zdroj: PLoS ONE
PLoS ONE, Vol 15, Iss 6, p e0234253 (2020)
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0234253
Popis: Oxidative status of maternal blood represents an important parameter of pregnancy that is involved in both, regulation of physiological processes and (if significantly altered) development of different pregnancy complications. Inherited thrombophilias represent genetic disorders that increase the risk of thromboembolism in pregnancy. Little is known about the impact of thrombophilia on the oxidative status of maternal blood. In this study, we analyzed oxidative status of blood of 56 women with pregnancies burdened by inherited thrombophilias. The status was established at three different trimesters using biochemical assays and electrochemical measurements, and it was compared to 10 age- and trimester-matching controls. Activities of superoxide dismutase, catalase, and glutathione reductase in the 1st and the 2nd trimester of thrombophilic pregnancy were lower than controls. Also, there was less oxidation in the plasma, according to higher concentration of reduced thiols and lower oxidation-reduction potential. Therefore, it appears that thrombophilic mothers do not experience oxidative stress in the circulation in the first two trimesters. However, the rise in GPx, GR and SOD activities in the 3rd trimester of thrombophilic pregnancy implies that the risk of oxidative stress is increased during the late pregnancy. These results are important for developing antioxidative treatment that could tackle thrombophilia-related pregnancy complications.
Databáze: OpenAIRE
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