Elevated endocannabinoid plasma levels are associated with coronary circulatory dysfunction in obesity
| Autor: | Vincent Makoundou, Fabrizio Montecucco, Elisabetta Harsch, Thomas H. Schindler, Gabriella Vincenti, Alessandra Quercioli, Zoltan Pataky, Aurélien Thomas, Vincenzo Di Marzo, Christian Staub, Yann Seimbille, Osman Ratib, Sebastian Carballo, François Mach, Sabine Steffens, Alain Golay |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Hemodynamics Coronary Disease 030204 cardiovascular system & hematology Overweight Body Mass Index 0302 clinical medicine ddc:616 2. Zero hunger ddc:615 Coronary disease 0303 health sciences Cold pressor test Blood flow Middle Aged 3. Good health Dipyridamole medicine.anatomical_structure Circulatory system Female medicine.symptom Cardiology and Cardiovascular Medicine medicine.drug medicine.medical_specialty Endothelium Polyunsaturated Alkamides Arachidonic Acids ddc:616.0757 Glycerides 03 medical and health sciences Coronary Circulation Internal medicine Cannabinoid Receptor Modulators medicine Humans Obesity ddc:613 Aged 030304 developmental biology business.industry ddc:614.1 medicine.disease Circulation Endocrinology Case-Control Studies Positron-Emission Tomography business Body mass index Endocannabinoids |
| Zdroj: | European heart journal European heart journal 32 (2011): 1369–1378. info:cnr-pdr/source/autori:Quercioli A, Pataky Z, Vincenti G, Makoundou V, Di Marzo V, Montecucco F, Carballo S, Thomas A, Staub C, Steffens S, Seimbille Y, Golay A, Ratib O, Harsch E, Mach F, Schindler TH./titolo:Elevated endocannabinoid plasma levels are associated with coronary circulatory dysfunction in obesity/doi:/rivista:European heart journal/anno:2011/pagina_da:1369/pagina_a:1378/intervallo_pagine:1369–1378/volume:32 European Heart Journal, Vol. 32, No 11 (2011) pp. 1369-1378 |
| ISSN: | 0195-668X |
| DOI: | 10.1093/eurheartj/ehr029 |
| Popis: | Aims Aim of this study was to evaluate a possible association between endocannabinoid (EC) plasma levels, such as anandamide (AEA) and 2-arachidonoylglycerol (2-AG), and coronary circulatory function in obesity. Methods and results Myocardial blood flow (MBF) responses to cold pressor test (CPT) and during pharmacological vasodilation with dipyridamole were measured with 13 N -ammonia PET/CT. Study participants ( n = 77) were divided into three groups based on their body mass index (BMI, kg/m2): control group 20≤ BMI |
| Databáze: | OpenAIRE |
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