Pulmonary Drug Delivery from the Taifun Dry Powder Inhaler Is Relatively Independent of the Patient's Inspiratory Effort
| Autor: | O.-P. Seppälä, S. P. Newman, T. Lankinen, G.R. Pitcairn |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine Budesonide Statistics Nonparametric Dosage form Pharmacokinetics Humans Medicine Gamma Cameras Pharmacology (medical) Radionuclide Imaging Aerosols Cross-Over Studies Lung Inhalation business.industry Nebulizers and Vaporizers Inhaler Middle Aged Thorax Crossover study Asthma Dry-powder inhaler Bronchodilator Agents Respiratory Function Tests Technetium Compounds medicine.anatomical_structure Anesthesia Female Powders business medicine.drug |
| Zdroj: | Journal of Aerosol Medicine. 13:97-104 |
| ISSN: | 1557-9026 0894-2684 |
| DOI: | 10.1089/089426800418622 |
| Popis: | The Taifun dry powder inhaler (Leiras OY, Turku, Finland) is a breath-actuated, multidose device, each metered dose containing 200 micrograms of budesonide. A two-way randomized crossover gamma scintigraphic study was performed in 10 asthmatic patients to determine the in vivo deposition pattern of budesonide inhaled from the Taifun. In vitro radiolabelling validation studies demonstrated that the radiolabel could be used as an accurate marker to assess in vivo drug deposition. Patients used either maximal inspiratory effort (targeted peak inhalation flow 30 L/min) or submaximal inspiratory effort (targeted peak inhalation flow 15 L/min) on each study day. Mean (S.D.) whole lung deposition (% of metered dose) was 34.3 (5.8)% and 29.6 (5.9)% for the two inhalation flows. The intersubject coefficient of variation in lung deposition was less than 20% on both study days. Drug was deposited uniformly across the central, intermediate, and peripheral lung regions for maximal and submaximal inspiratory efforts. The study suggests that the Taifun is a superior drug delivery device compared with many other inhalers, in terms of the amount of drug deposited in the lungs, the reproducibility of the lung dose, and the relative flow--independence of lung deposition. |
| Databáze: | OpenAIRE |
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