Irisin and Visfatin Predicts Severity of Diabetic Nephropathy
| Autor: | Sreejith Parameshwaran, Hanumanthappa Nandeesha, Ramalingam Mageswari, Kolar Vishwanath Vinod, Magadi Gopalakrishna Sridhar |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Adiponectin business.industry Clinical Biochemistry Albumin Urine Albumin/creatinine ratio medicine.disease Gastroenterology Nephropathy Diabetic nephropathy 03 medical and health sciences 030104 developmental biology 0302 clinical medicine 030220 oncology & carcinogenesis Internal medicine Diabetes mellitus medicine In patient Original Research Article business |
| Zdroj: | Indian J Clin Biochem |
| ISSN: | 0974-0422 0970-1915 |
| DOI: | 10.1007/s12291-018-0749-7 |
| Popis: | Although the roles of irisin and visfatin have been well established in diabetes mellitus, there are limited studies about their association in diabetic nephropathy. The present study was designed to assess the levels of irisin and visfatin and their association with the severity of diabetic nephropathy. 43 diabetic nephropathy cases and 43 diabetic subjects without nephropathy were enrolled in the study. Serum levels of irisin and visfatin were compared in both the groups. Irisin and visfatin were significantly increased in diabetic nephropathy cases when compared with diabetes subjects without nephropathy. eGFR was negatively correlated with visfatin (r = −0.323, p = 0.034), irisin (r = −0.324, p = 0.034), urine albumin (r = −0.443, p = 0.003) and albumin creatinine ratio (r = −0.419, p = 0.005) in patients with diabetic nephropathy. Visfatin was significantly elevated in stage IV nephropathy compared with stage III nephropathy. We conclude that irisin and visfatin are elevated in diabetic nephropathy and can be an index of its severity. |
| Databáze: | OpenAIRE |
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