Childhood Acute Leukemia, Early Common Infections, and Allergy: The ESCALE Study
| Autor: | Anne Lambilliotte, Yves Bertrand, Arnaud Petit, Alain Robert, Jérémie Rudant, André Baruchel, Jacqueline Clavel, Francoise Mechinaud, Pierre Bordigoni, Julie Tandonnet, Florence Menegaux, Denis Hémon, Gérard Michel, Laurent Orsi, Geneviève Margueritte |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Adolescent Acute myeloblastic leukemia Epidemiology Population Infections Surveys and Questionnaires Acute lymphocytic leukemia Hypersensitivity Odds Ratio medicine Animals Humans Child education Acute leukemia education.field_of_study business.industry Incidence Incidence (epidemiology) Infant Child Day Care Centers Odds ratio Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease Asthma Leukemia Myeloid Acute Leukemia Breast Feeding Research Design Case-Control Studies Child Preschool Regression Analysis Female France Birth Order business Breast feeding |
| Zdroj: | American Journal of Epidemiology. 172:1015-1027 |
| ISSN: | 1476-6256 0002-9262 |
| DOI: | 10.1093/aje/kwq233 |
| Popis: | This study investigated the role of factors considered related to early stimulation of the immune system in the etiology of childhood acute leukemia. The national registry-based case-control study ESCALE was carried out in France in 2003-2004. Population controls were frequency matched to cases on age and gender. Data were obtained from structured telephone questionnaires administered to mothers. Odds ratios were estimated using unconditional regression models adjusted for potential confounders. Included were 634 acute lymphoblastic leukemia cases, 86 acute myeloblastic leukemia cases, and 1,494 controls aged ≥1 year. Negative associations were observed between acute lymphoblastic leukemia and birth order (P for trend < 0.0001), attendance at a day-care center before age 1 year (odds ratio (OR) = 0.8, 95% confidence interval (CI): 0.6, 1.1), prolonged breastfeeding (OR = 0.7, 95% CI: 0.5, 1.0), repeated early common infections (OR = 0.7, 95% CI: 0.6, 0.9), regular contact with farm animals (OR = 0.6, 95% CI: 0.5, 0.8), frequent farm visits in early life (OR = 0.4, 95% CI: 0.3, 0.6), and history of asthma (OR = 0.7, 95% CI: 0.4, 1.0) or eczema (OR = 0.7, 95% CI: 0.6, 0.9). Results support the hypothesis that repeated early infections and asthma may play a role against childhood acute leukemia. |
| Databáze: | OpenAIRE |
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