The choroid plexus is a key cerebral invasion route for T cells after stroke
| Autor: | Gaby Enzmann, Ruiyao Cai, Joan Montaner, Corinne Benakis, Ivana Lazarevic, Britta Engelhardt, Nikolaus Plesnila, Denis Vivien, Sabine Liebscher, Xiang Mao, Christof Haffner, Gemma Llovera, Alireza Ghasemigharagoz, Lilja Meissner, Rainer Malik, Arthur Liesz, Thomas Arzberger, Ali Ertürk |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Pathology medicine.medical_specialty T-Lymphocytes Population Ischemia Mice Transgenic 610 Medicine & health Biology Brain Ischemia Pathology and Forensic Medicine Lesion 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Cell Movement Cortex (anatomy) Brain Injuries Traumatic medicine Animals Humans Myeloid Cells cardiovascular diseases education Stroke Chemokine CCL2 Neuroinflammation Aged Aged 80 and over Cerebral Cortex education.field_of_study medicine.disease Pathophysiology Mice Inbred C57BL Disease Models Animal 030104 developmental biology medicine.anatomical_structure Choroid Plexus Female Choroid plexus Neurology (clinical) medicine.symptom 030217 neurology & neurosurgery |
| Zdroj: | Llovera, Gemma; Benakis, Corinne; Enzmann, Gaby; Cai, Ruiyao; Arzberger, Thomas; Ghasemigharagoz, Alireza; Mao, Xiang; Malik, Rainer; Lazarevic, Ivana; Liebscher, Sabine; Ertürk, Ali; Meissner, Lilja; Vivien, Denis; Haffner, Christof; Plesnila, Nikolaus; Montaner, Joan; Engelhardt, Britta; Liesz, Arthur (2017). The choroid plexus is a key cerebral invasion route for T cells after stroke. Acta neuropathologica, 134(6), pp. 851-868. Springer 10.1007/s00401-017-1758-y |
| DOI: | 10.7892/boris.111257 |
| Popis: | Neuroinflammation contributes substantially to stroke pathophysiology. Cerebral invasion of peripheral leukocytes-particularly T cells-has been shown to be a key event promoting inflammatory tissue damage after stroke. While previous research has focused on the vascular invasion of T cells into the ischemic brain, the choroid plexus (ChP) as an alternative cerebral T-cell invasion route after stroke has not been investigated. We here report specific accumulation of T cells in the peri-infarct cortex and detection of T cells as the predominant population in the ipsilateral ChP in mice as well as in human post-stroke autopsy samples. T-cell migration from the ChP to the peri-infarct cortex was confirmed by in vivo cell tracking of photoactivated T cells. In turn, significantly less T cells invaded the ischemic brain after photothrombotic lesion of the ipsilateral ChP and in a stroke model encompassing ChP ischemia. We detected a gradient of CCR2 ligands as the potential driving force and characterized the neuroanatomical pathway for the intracerebral migration. In summary, our study demonstrates that the ChP is a key invasion route for post-stroke cerebral T-cell invasion and describes a CCR2-ligand gradient between cortex and ChP as the potential driving mechanism for this invasion route. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|