A chemoselective and continuous synthesis of m-sulfamoylbenzamide analogues
| Autor: | Christian V. Stevens, Thomas S. A. Heugebaert, Frank Van Breusegem, Pavel Kerchev, Tom van der Meer, Arno Verlee |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
flow chemistry
CONTINUOUS-FLOW PROCESS m-sulfamoylbenzamide 010402 general chemistry 01 natural sciences Full Research Paper Catalysis lcsh:QD241-441 m-sulfamoylbenzamide analogues chemistry.chemical_compound Benzoyl chloride lcsh:Organic chemistry SIRT2 Organic chemistry ACTIVE PHARMACEUTICAL INGREDIENTS lcsh:Science PERSPECTIVE 010405 organic chemistry Chemistry DERIVATIVES POTENT Organic Chemistry medium-throughput synthesis Combinatorial chemistry Small molecule SAFE 0104 chemical sciences lcsh:Q Selectivity INHIBITORS analogues |
| Zdroj: | Beilstein Journal of Organic Chemistry BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY Beilstein Journal of Organic Chemistry, Vol 13, Iss 1, Pp 303-312 (2017) |
| ISSN: | 1860-5397 |
| Popis: | For the synthesis of m-sulfamoylbenzamide analogues, small molecules which are known for their bioactivity, a chemoselective procedure has been developed starting from m-(chlorosulfonyl)benzoyl chloride. Although a chemoselective process in batch was already reported, a continuous-flow process reveals an increased selectivity at higher temperatures and without catalysts. In total, 15 analogues were synthesized, using similar conditions, with yields ranging between 65 and 99%. This is the first automated and chemoselective synthesis of m-sulfamoylbenzamide analogues. |
| Databáze: | OpenAIRE |
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