The role of itch and pain modulation in the prediction of phototherapy outcomes: a prospective cohort study
| Autor: | Pora Kuperman, Michal Ramon, Sarit Yakov, Michal Granot |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Oncology
medicine.medical_specialty Pain Painful Stimulation Sensory system Dermatology Summation 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Internal medicine parasitic diseases otorhinolaryngologic diseases Humans Medicine Prospective Studies skin and connective tissue diseases Prospective cohort study Sensitization 030203 arthritis & rheumatology Pain modulation business.industry Pruritus Phototherapy Peripheral Treatment Outcome medicine.anatomical_structure Facilitation business |
| Zdroj: | Journal of Dermatological Treatment. 33:1037-1041 |
| ISSN: | 1471-1753 0954-6634 |
| Popis: | OBJECTIVES Ability to predict which chronic itch patients will benefit from particular treatments is a challenge. Common features in itch and pain in respect to sensory elicitation, and mechanisms of processing including sensitization and inhibition at the peripheral and central levels, may serve to understand variability in treatment outcomes. As such this study aimed to explore whether phototherapy outcomes can be predicted by psychophysical parameters of pain and itch modulatory processing. METHODS Prospective cohort study on chronic-itch patients (n = 44) assessed before 20 treatments of NB UVB. Level of itch and pain reduction following painful stimulation (reflecting the 'pain inhibits pain' phenomenon) used to assess the top-down modulation response efficacy. Magnitude of Conditioned Pain Modulation (CPM) for itch (CPM-itch) and for pain (CPM-pain) (reflecting inhibition) and magnitude of temporal summation (TS) of pain (reflecting ascending facilitation pathways) assessed to predict treatment effect. RESULTS Higher improvement of itch symptoms following phototherapy was correlated with more efficient CPM-itch (r = 0.62, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|