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Kulczyński Marcin, Marciniec Michał, Sapko Klaudia, Ficek Remigiusz. Analysis of current epilepsy treatment guidelines. Journal of Education, Health and Sport. 2019;9(8):328-342.eISNN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.3374777 http://ojs.ukw.edu.pl/index.php/johs/article/view/7317 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2019; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 10.08.2019. Revised: 20.08.2019. Accepted: 22.08.2019. Analysis of current epilepsy treatment guidelines Marcin Kulczyński*, Michał Marciniec, Klaudia Sapko, Remigiusz Ficek Chair and Department of Neurology, Medical University of Lublin, Poland *Corresponding author: Marcin Kulczyński ul. K. Jaczewskiego 8 20-954 Lublin, Poland tel. +48817244718 e-mail: mk.marcin.kulczynski@gmail.com ABSTRACT Introduction: In 2017, the International League Against Epilepsy (ILAE) published a new classification of seizures. The purpose of this publication is to analyze the use of antiepileptic drugs in epilepsy therapy depending on the types of seizures classified according to ILAE 2017. State of the art:The new basic classification emphasizes mainly the location, where seizures begin in the brain, as the most important criterion to classify epileptic seizures. In focal onset seizures, 1stline of treatment in children is oxcarbazepine, while carbamazepine, levetiracetam, phenytoin and zonisamide is 1stchoice in younger adults and gabapentin and lamotrigine in elderly patients. In younger adults valproic acid can be considered as second line treatment. In generalized tonic and atonic seizures carbamazepine, phenobarbital, phenytoin, topiramate, oxcarbazepine and valproic acid can be used both in children and adults. Safe and effective drugs in myoclonic and myoclonic-atonic seizures in all age groups are topiramate and valproic acid. In absence seizures, 1stline treatment in children is ethosuximide (used exclusively in this seizures type) and valproic acid, while carbamazepine, lamotrigine, oxcarbazepine, phenobarbital, phenytoin, topiramate, valproic acid, gabapentin, levetiracetam and vigabatrin are commonly used in adult patients. Non-pharmacological approaches, used in refractory epilepsy, include: surgical resection of the seizure focus, the ketogenic diet, vagus nerve stimulation and responsive neurostimulation. Summary: The new ILAE classification corresponds well with the old guidelines well, which leads to simplifying and spreading the knowledge about epileptic seizures treatment. Key words: Epilepsy; antiepileptic drugs; epileptic seizures |
