Impaired sperm aggregation in Adam2 and Adam3 null mice
| Autor: | Heejin Choi, Boyeon Lee, Cecil Han, Jun Tae Kwon, Sora Jin, Inju Park, Chunghee Cho |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Male
Infertility endocrine system Andrology Mice medicine Animals Zona pellucida Zona Pellucida reproductive and urinary physiology Cell Aggregation Mice Knockout Membrane Glycoproteins biology urogenital system Obstetrics and Gynecology medicine.disease Spermatozoa Sperm In vitro Cell aggregation ADAM Proteins Membrane glycoproteins Fertilins medicine.anatomical_structure Reproductive Medicine embryonic structures Knockout mouse biology.protein Female ADAM3 |
| Zdroj: | Fertility and Sterility. 93:2754-2756 |
| ISSN: | 0015-0282 |
| DOI: | 10.1016/j.fertnstert.2010.03.013 |
| Popis: | Previous studies have shown that sperm from Adam2 and Adam3 knockout mice have defective migration in the female reproductive tracts and cannot bind to the egg's zona pellucida (ZP), which leads to infertility. Here, we report that Adam2 and Adam3 knockout sperm have severely impaired sperm aggregation and that this defect is not restored over time during in vitro cultivation, suggesting the requirement of ADAM2 and ADAM3 in normal sperm association. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|