How the cytochrome 7a1 (CYP7A1) and ATP-binding cassette G8 (ABCG8) genetic variants affect atorvastatin response among type 2 diabetic patients attending the University of Jordan Hospital
| Autor: | Yazun Jarrar, Malek Zihlif, Sarah Abdullah, Eyada Abed, Hussam H. Alhawari |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
050101 languages & linguistics
medicine.medical_specialty Statin Genotype medicine.drug_class Atorvastatin Blood lipids 02 engineering and technology Gastroenterology Polymorphism Single Nucleotide Adenosine Triphosphate Diabetes mellitus Internal medicine 0202 electrical engineering electronic engineering information engineering medicine Humans 0501 psychology and cognitive sciences Pharmacology (medical) Cholesterol 7-alpha-Hydroxylase Glycemic Pharmacology medicine.diagnostic_test business.industry 05 social sciences ATP Binding Cassette Transporter Subfamily G Member 8 nutritional and metabolic diseases medicine.disease Hospitals Diabetes Mellitus Type 2 Cytochromes lipids (amino acids peptides and proteins) 020201 artificial intelligence & image processing Lipid profile business medicine.drug Lipoprotein |
| Zdroj: | International journal of clinical pharmacology and therapeutics. 59(2) |
| ISSN: | 0946-1965 |
| Popis: | Objective There is a high inter-individual variation in atorvastatin response. This study aimed to identify the influences of the CYP7A1 rs3808607, ABCG8 rs11887534, and ABCG8 rs4148217 genetic variants on the lipid profile and atorvastatin response among Arab Jordanian patients with type 2 II diabetes mellitus (T2DM). Materials and methods 117 patients with T2DM and on atorvastatin therapy, the most common statin used at the University of Jordan Hospital, were genotyped for the CYP7A1 rs3808607, ABCG8 rs11887534, and ABCG8 rs4148217 genetic variants using PCR-restriction fragment length polymorphism. The baseline blood lipid and glycemic parameters were analyzed in the University of Jordan Hospital's laboratory before and after 3 months of atorvastatin administration. Results Patients carrying the homozygote ABCG8 rs4148217 genotype have less total cholesterol (TC) (157.7 mg/dL) and low-density lipoprotein (LDL) (95.5 mg/dL) than the wild genotype (TC (192.4 mg/dL) and LDL (138.3 mg/dL)). Although these differences did not reach statistical significance (ANOVA, p-value > 0.17). There were no significant associations between the CYP7A1 rs3808607 and ABCG8 rs11887534 polymorphisms and baseline lipid and glycemic parameters (p > 0.12). Overall, no significant association was found between these polymorphisms and atorvastatin response (p > 0.13). Conclusion It seems that the CYP7A1 rs3808607, ABCG8 rs11887534, and ABCG8 rs4148217 genetic variants do not explain the inter-individual variation in atorvastatin response and lipid baseline profile among Jordanian T2DM patients of Arabic origin. |
| Databáze: | OpenAIRE |
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