Hand, shoulder and back stiffness in long-term type 1 diabetes; cross-sectional association with skin collagen advanced glycation end-products. The Dialong study
| Autor: | Vincent M. Monnier, David R. Sell, Jens Ivar Brox, Dag Sigurd Fosmark, Kristine Bech Holte, Kristian F. Hanssen, Niels Gunnar Juel, Tore Julsrud Berg |
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| Rok vydání: | 2017 |
| Předmět: |
Glycation End Products
Advanced Male musculoskeletal diseases 0301 basic medicine Shoulder medicine.medical_specialty Contracture Cross-sectional study Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Internal medicine Diabetes mellitus Prevalence Internal Medicine medicine Humans Musculoskeletal Diseases Pentosidine Carpal tunnel syndrome Aged Skin Back Type 1 diabetes business.industry Frozen shoulder Odds ratio Middle Aged Hand medicine.disease Surgery Cross-Sectional Studies Diabetes Mellitus Type 1 030104 developmental biology chemistry Female Collagen Trigger finger business |
| Zdroj: | Journal of Diabetes and its Complications. 31:1408-1414 |
| ISSN: | 1056-8727 |
| DOI: | 10.1016/j.jdiacomp.2017.06.007 |
| Popis: | Aims We aimed to: (i) estimate the prevalence of Dupuytren's disease, trigger finger, carpal tunnel syndrome and frozen shoulder; (ii) assess stiffness of the hand, shoulder and back; and (iii) explore the association of joint stiffness with both long-term HbA 1c and collagen advanced glycation end-products (AGEs) in long-term type 1 diabetes mellitus (T1DM). Methods Patients with T1DM from 1970 or earlier attending a specialized diabetes center were included in this cross-sectional controlled study. We collected HbA 1 /HbA 1c measurements from 1980 to 2015 and data on hand and shoulder diagnoses and joint stiffness through interviews, charts, and standardized examination. Skin biopsies were analyzed for collagen AGEs by liquid chromatography-mass spectrometry. Results Lifetime prevalence of hand and shoulder diagnoses in the diabetes group (n=102) ranged from 37%–76% (frozen shoulder) versus 11%–15% in controls (n=73) (p 1c (odds ratio 2.01 [95% CI 1.10–3.7]) and the AGEs methyl-glyoxal-lysine-dimer (odds ratio 1.68 [95% CI 1.03–2.73]) and pentosidine (odds ratio 1.81 [95% CI 1.04–3.16]). Conclusions Patients with T1DM >45years had a very high prevalence of hand and shoulder diagnoses versus controls. Joint stiffness was associated with collagen AGEs. However, joint biopsies and prospective studies must explore this association further. |
| Databáze: | OpenAIRE |
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