Skeletal muscle resting membrane potential in potassium deficiency
| Autor: | Gordon L. Bilbrey, Luis Herbin, Norman W. Carter, James P. Knochel |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
medicine.medical_specialty
Sodium Potassium Biopsy chemistry.chemical_element Membrane Potentials Dogs Chlorides Muscular Diseases Internal medicine medicine Animals Myopathy Potassium Deficiency Membrane potential Acid-Base Equilibrium Electromyography Muscles Skeletal muscle Water General Medicine Anatomy Articles Rats Endocrinology medicine.anatomical_structure chemistry Potassium deficiency medicine.symptom Intracellular Muscle contraction Muscle Contraction |
| Zdroj: | The Journal of clinical investigation. 52(12) |
| ISSN: | 0021-9738 |
| Popis: | The resting transmembrane potential of skeletal muscle (E(m)) is thought to be a function of the ratio of intracellular to extracellular potassium concentration ([K(i)]/[K(o)]). In potassium deficiency, the fall of [K(i)] is proportionately less than the fall of [K(o)], thus theoretically predicting a rise of E(m). To examine this theory and to characterize E(m) in kaliopenic myopathy, muscle composition and E(m) were measured during moderate (n = 5) and severe (n = 11) K deficiency in the dog and compared with measurements in the severely K-deficient rat (n = 10). Mean measured E(m) rose during moderate K deficiency in four of five dogs (-85.4 to -94.6 mV) and during severe K deficiency in the rat (-89.1 to -94.9 mV). Both values closely approximated the increase in E(m) predicted by the Goldman equation. In contrast, during severe K deficiency in the dog, a significant decline (P < 0.001) of mean E(m) to -55 mV was observed.Since skeletal myopathy and paralysis do not occur in the rat as a consequence of K deficiency, the observation that E(m) falls as paralysis occurs in the unexercised dog suggests that alteration of muscle membrane function may play a role in kaliopenic myopathy. Such an event could explain the ease with which frank muscle necrosis may be induced by exercise in the K-deficient dog. |
| Databáze: | OpenAIRE |
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