Region-specific differences in colorectal cancer: Slovakia and Hungary have highest incidence in Europe
| Autor: | E Ginter, V Simko |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Slovakia
Economics and Econometrics medicine.medical_specialty Croatia Colorectal cancer 03 medical and health sciences 0302 clinical medicine Region specific Risk Factors Epidemiology Materials Chemistry Media Technology medicine Humans Mortality neoplasms Czech Republic Hungary business.industry Incidence Incidence (epidemiology) Forestry Inflammatory Bowel Diseases medicine.disease digestive system diseases Ashkenazi jews 030220 oncology & carcinogenesis East europe Cohort High incidence Colorectal Neoplasms business Genome-Wide Association Study Demography |
| Zdroj: | Bratislava Medical Journal. 116:66-71 |
| ISSN: | 1336-0345 |
| Popis: | Epidemiological data on colorectal cancer (CRC) exhibit high incidence in Central East Europe. Hungary, Slovakia and Croatia represent the lead. For decades it was the Czech Republic but it attained the fourth rank after the mid-2000. Remarkably, the Ashkenazi Jews who imigrated to the USA from Central Europe have the highest incidence of CRC among US minorities. They also have high incidence of inflammatory bowel disease, a risk for CRC. Notably, countries surrounding the Central European focus of CRC, Austria, Germany, Poland, Romania, Ukraine and Russia have substantially lower incidence. CRC in Central Europe has higher incidence than CRC among the highest at-risk cohort in the USA, the elderly blacks. Research and the genome wide screening identified genetic mutations associated with CRC in Ashkenazis from Central Europe. Some risk factors for CRC are non genotypic as evidenced by wide variation in CRC incidence in the course of only a few decades. Recent trends offer hope that identification of the non-innate pathogenic mechanisms would potentially reduce the burden of this third most lethal malignancy (Tab. 1, Fig. 4, Ref. 40). |
| Databáze: | OpenAIRE |
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