Strongest correlation of HbA(1c) with 1-month-earlier glucose levels in type 2 diabetes

Autor: Michiyo Fukudome, Nobuyuki Koriyama, Eriko Fukushige, Hiroshi Hashiguchi, Kaori Kato, Chuwa Tei, Yuko Ikeda, Junko Yano, Katsumi Aso, Mitsuhiro Nakazaki
Rok vydání: 2004
Předmět:
Zdroj: Diabetes research and clinical practice. 63(3)
ISSN: 0168-8227
Popis: We examined the correlations of hemoglobin A(1c) (HbA(1c)) with each plasma glucose (PG) level obtained at 0 (the same day), 1 and 2 month(s) prior to HbA(1c) determination. Data were from glycemic profiles of four patients of type 2 diabetes mellitus treated with tablets whose HbA(1c) and pre- and post-breakfast PG levels were monitored each month. There was no significant difference in the correlation coefficients in cases 1 and 2, who presented with linear glycemic time courses. In contrast, HbA(1c) correlated with 1-month-earlier pre-breakfast PG level more strongly than 2-month-earlier post-breakfast PG level in cases 3 and 4, and than same-day post-breakfast PG level in case 3 (P0.05, ANOVA). The cases 3 and 4 presented with fluctuating glycemic time courses. Samples were separated into upslope's and downslope's sections according to HbA(1c) fluctuation in the latter two cases. Reflecting around the 1-month lag between HbA(1c) and PG, the two sections' regression lines for PG versus HbA(1c) corresponded in the only samples related to 1-month-earlier pre- and post-breakfast PG (t-test). In conclusion, it appears that pre- and post-breakfast PG levels are the most reliable predictors of 1-month-later HbA(1c) in type 2 diabetic outpatients who undergo medical examinations every month.
Databáze: OpenAIRE
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