Plasma von Willebrand factor and thrombomodulin as markers of vascular disorders in patients undergoing regular hemodialysis therapy
| Autor: | Yoshihiro Nakamura, Yoshiko Chida, Shuji Kodama, Kouji Suzuki, Tatsuya Hayashi, Fumiaki Marumo, Shigeo Tomura, Fusae Deguchi, Yasuo Ohno |
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| Rok vydání: | 1990 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Receptors Cell Surface Thrombomodulin Antigen Von Willebrand factor Renal Dialysis hemic and lymphatic diseases Internal medicine von Willebrand Factor Blood plasma medicine Humans Vascular Diseases biology Chemistry Vascular disease Thrombin Hematology Middle Aged medicine.disease Endothelial stem cell Blood pressure Endocrinology biology.protein Female Receptors Thrombin Hemodialysis Biomarkers |
| Zdroj: | Thrombosis Research. 58:413-419 |
| ISSN: | 0049-3848 |
| Popis: | Increased plasma levels of von Willebrand factor antigen (vWF:Ag) are regarded as reflecting the release reaction by vascular endothelial cells and/or endothelial cell injury, and increased levels of thrombomodulin (TM) antigen as reflecting damage to endothelial cells. We investigated changes in plasma vWF:Ag and TM antigen levels during the course of regular hemodialysis treatment (RDT) in 14 patients undergoing RDT in order to evaluate the effect of hemodialysis (HD) on endothelial cells. vWF:Ag and TM were both measured by the sandwich EIA method. Predialysis levels of vWF:Ag and TM in RDT patients were both significantly higher than normal control values. Neither patient age nor blood pressure was not correlated with predialysis vWF:Ag and TM levels. Both vWF:Ag and TM levels significantly increased during a single HD session. There was a positive correlation between predialysis TM levels and duration of HD and an inverse correlation between the amount of vWF:Ag released during HD and duration of HD. It appears that HD procedures induce stimulation and damage of endothelial cells and that long-term, recurrent HD treatment may predispose to vascular disorders. |
| Databáze: | OpenAIRE |
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