Immunology of Diabetes Society T-Cell Workshop: HLA class I tetramer-directed epitope validation initiative T-Cell Workshop Report-HLA Class I Tetramer Validation Initiative

Autor:	Matthieu Scotto, Eddie A. James, Christian Boitard, Colin M. Dayan, O. Lou, Nicholas Jospe, Peter A. Gottlieb, Ivana Durinovic-Belló, Rebecca Wagner, Jerill Thorpe, Claire Nicola Janicki, Roberto Mallone, Florence Susan Wong, Lisa Fitzgerald-Miller
Rok vydání:	2011
Předmět:	Adult Enzyme-Linked Immunospot Assay Adolescent Endocrinology Diabetes and Metabolism T cell Epitopes T-Lymphocyte Human leukocyte antigen CD8-Positive T-Lymphocytes medicine.disease_cause Epitope Autoimmunity Interferon-gamma Endocrinology Antigen Internal Medicine medicine Humans Insulin Interferon gamma Protein Precursors HLA-A Antigens Glutamate Decarboxylase business.industry ELISPOT Histocompatibility Antigens Class I Virology Diabetes Mellitus Type 1 medicine.anatomical_structure Immunology business CD8 medicine.drug
Zdroj:	Diabetes/Metabolism Research and Reviews. 27:720-726
ISSN:	1520-7552
Popis:	BACKGROUND: Identification of T-cell reactivity to β-cell antigen epitopes is an important goal for studying pathogenesis and for designing and monitoring of immunotherapeutic interventions in type 1 diabetes (T1D). METHODS: We performed a multicentre validation of known human leukocyte antigen (HLA) class I CD8+ T-cell epitopes. To this end, peripheral blood T-cell responses were measured in 35 recently (
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03b37fd2fbcd35842e05eeb5062c98da https://doi.org/10.1002/dmrr.1243 Zobrazit plný text záznamu Plný text