Neutrophilic migration through capillarylike micropores: influence of pulmonary passage
| Autor: | S. Kleeberg, Martin Stauch, H. Seibold, G. Rödel, Otto Haferkamp |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Male Pulmonary Circulation medicine.medical_specialty Adolescent Neutrophils Heart Ventricles Hypertension Pulmonary Molecular Sequence Data Heart Valve Diseases Chemokinesis Pulmonary Artery Angina Pectoris Microcirculation Angina Cell Movement Internal medicine medicine.artery Drug Discovery medicine Humans Amino Acid Sequence Lung Genetics (clinical) Aged Respiratory distress business.industry Zymosan General Medicine Middle Aged medicine.disease Pulmonary hypertension N-Formylmethionine Leucyl-Phenylalanine Chemotaxis Leukocyte medicine.anatomical_structure Ventricle Pulmonary artery Cardiology Molecular Medicine Female business |
| Zdroj: | The Clinical Investigator. 72 |
| ISSN: | 1432-1440 0941-0198 |
| DOI: | 10.1007/bf00231113 |
| Popis: | We report the effect of pulmonary passage on random migration and chemokinesis of neutrophils through capillarylike pores under the in vitro condition of Boyden's test. Neutrophils were isolated either from the left ventricle or from the pulmonary artery of patients who underwent coronary angiography due to suspected angina pectoris or valvular heart disease. In all 14 cases left ventricle neutrophils showed significantly enhanced chemotactic-activated migration compared with pulmonary artery neutrophils. Pulmonary passage also influenced the random migration of neutrophils, except for those derived from five patients suffering from pulmonary hypertension. Our findings might indicate that accumulation of neutrophils in the capillaries of the normal lung is counteracted by a change in neutrophilic migration behavior during pulmonary passage, thus avoiding increased neutrophilic sequestration in pulmonary microcirculation as observed in adult respiratory distress syndrome. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink