Bacterial colonization in respiratory secretions from acute and recurrent wheezing infants and children
| Autor: | Yoko Nagayama, Shigeru Nakayama, Tsuyosi Toba, Yoichi Kohno, Kazuko Taguchi, Toshikazu Tsubaki, Kyoko Sawada |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Immunology Moraxella catarrhalis Pulmonary Disease Chronic Obstructive Recurrence Internal medicine Lower respiratory tract infection medicine Immunology and Allergy Humans Colonization Child Asthma Respiratory Sounds biology Bacteria business.industry Incidence (epidemiology) Respiratory disease Infant Newborn Sputum Infant biology.organism_classification medicine.disease Pneumonia Child Preschool Pediatrics Perinatology and Child Health Acute Disease Female medicine.symptom business |
| Zdroj: | Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology. 18(2) |
| ISSN: | 0905-6157 |
| Popis: | Lower respiratory tract infection in childhood often results in airway obstruction, characterized by wheezing. However, contribution of bacterial colonization to the wheezy state in children remains unclear. Wheezing and non-wheezing children requiring hospitalization were classified into three groups: (i) wheezing children having a past history of recurrent wheezing; (ii) wheezing children without such history; and (iii) non-wheezing children as control subjects. Respiratory secretions as sputum were analyzed microscopically, and cultured. Cultured pathogenic bacterial species in sputum were categorized into two subgroups according to their amounts, i.e., dominant and non-dominant amounts of colonies. Incidence of bacterial colonization and wheezing were assessed. Hospitalized children were mainly 1- to 2-yr old, and rapidly decreased in number for older ages. Children in the three groups belonged to different clinical entities. Children in the recurrent wheezing group were highly sensitized to mite allergens, and still required hospitalization after 2 yr of age. Incidence of bacterial colonization was similar between the three groups. Dominant and non-dominant amounts of bacterial colonization were 170/997 (17.1%) and 170/997 (17.1%), respectively, in the recurrent wheezing group; 28/146 (19.2%) and 35/146 (24.0%), respectively, in the acute wheezing group; and 15/56 (26.8%) and 7/56 (12.5%), respectively, in the non-wheezing group. Regardless of the presence of wheezing, bacterial colonization commonly occurred at a young age in the three groups. In recurrent wheezing children, boys (122/611, 20.0%) carried non-dominant amounts of bacteria more frequently than girls (48/386, 12.4%) (p < 0.01). Boys showed predominant wheezing and susceptibility to bacterial colonization. Assessment of bacterial colonization allowed us to characterize asthma onset and outgrowth in childhood. |
| Databáze: | OpenAIRE |
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