Meeting Report
| Autor: | D. L. Hutto, Prachi Sharma, Heather A. Simmons, Richard J. Montali, S. Cummings Macri, M. Owston, A. Bradley, Shiva Kumar Shanmukhappa, Saravanan Kaliyaperumal, Keith Mansfield, Lisa M. Kattenhorn, E. Gruber-Dujardin, Linda J. Lowenstine, D. Liu, Basel T. Assaf, Andrew D. Miller, Martha A. Delaney, Kerstin Mätz-Rensing, C. Tremblay, L. D. Schmidt, J. F. Reindel, Audrey Baldessari, Karen A. Terio, J. E. Markovits, Joseph L. Mankowski, J. M. Cline, Vito G. Sasseville, Cynthia L. Courtney, Carole Harbison |
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| Rok vydání: | 2012 |
| Předmět: |
Animal Experimentation
Male Primates medicine.medical_specialty Biomedical Research Population Drug Evaluation Preclinical Animals Wild Gorilla medicine.disease_cause Macaque Article biology.animal medicine Animals Primate Animal testing education education.field_of_study General Veterinary biology Bonobo Primate Diseases Cytomegalovirus biology.organism_classification Macaca mulatta Macaca fascicularis Family medicine Models Animal Immunology Animals Zoo Female |
| Zdroj: | Veterinary Pathology. 49:1057-1069 |
| ISSN: | 1544-2217 0300-9858 |
| DOI: | 10.1177/0300985812461655 |
| Popis: | The combination of loss of habitat, human population encroachment, and increased demand of select nonhuman primates for biomedical research has significantly affected populations. There remains a need for knowledge and expertise in understanding background findings as related to the age, source, strain, and disease status of nonhuman primates. In particular, for safety/biomedical studies, a broader understanding and documentation of lesions would help clarify background from drug-related findings. A workshop and a minisymposium on spontaneous lesions and diseases in nonhuman primates were sponsored by the concurrent Annual Meetings of the American College of Veterinary Pathologists and the American Society for Veterinary Clinical Pathology held December 3–4, 2011, in Nashville, Tennessee. The first session had presentations from Drs Lowenstine and Montali, pathologists with extensive experience in wild and zoo populations of nonhuman primates, which was followed by presentations of 20 unique case reports of rare or newly observed spontaneous lesions in nonhuman primates (see online files for access to digital whole-slide images corresponding to each case report at http://www.scanscope.com/ACVP%20Slide%20Seminars/2011/Primate%20Pathology/view.apml). The minisymposium was composed of 5 nonhuman-primate researchers (Drs Bradley, Cline, Sasseville, Miller, Hutto) who concentrated on background and spontaneous lesions in nonhuman primates used in drug safety studies. Cynomolgus and rhesus macaques were emphasized, with some material presented on common marmosets. Congenital, acquired, inflammatory, and neoplastic changes were highlighed with a focus on clinical, macroscopic, and histopathologic findings that could confound the interpretation of drug safety studies. |
| Databáze: | OpenAIRE |
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