Comparison of Immature Platelet Fraction (IPF) in Patients with Central Thrombocytopenia and Peripheral Thrombocytopenia
| Autor: | Zahid Asgher, Samina Qamar, Sindhu Rehman, Ambareen Hamid, Sobia Ashraf |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Blood Platelets
Male medicine.medical_specialty medicine.diagnostic_test business.industry Platelet Count Bone marrow failure Complete blood count General Medicine Immature Platelet medicine.disease Gastroenterology Thrombocytopenia Peripheral medicine.anatomical_structure Cross-Sectional Studies Interquartile range Internal medicine Biopsy medicine Humans Platelet Female Bone marrow business |
| Zdroj: | Journal of the College of Physicians and Surgeons--Pakistan : JCPSP. 30(8) |
| ISSN: | 1681-7168 |
| Popis: | Objective: To determine immature platelet fraction (IPF) in patients with thrombocytopenia and correlation with their bone marrow findings and to determine its predictive value in differentiating peripheral (hyper destructive) thrombocytopenia from central (hypo-productive) thrombocytopenia. STUDY DESIGN Cross-sectional comparative study. PLACE AND DURATION OF STUDY King Edward Medical University (KEMU) and Doctors Hospital Lahore, from December 2018 to February 2019. METHODOLOGY Patients of both genders and all age groups with thrombocytopenia presenting for bone marrow biopsy were included in the study. Clinical data, complete blood count (CBC) sample in EDTA, bone marrow aspirate and trephine biopsy were obtained. Slides were prepared and reviewed. CBC sample was analysed for counts and IPF in Doctors Hospital Laboratory within 4 hours of collection. RESULTS According to bone marrow findings, patients were grouped under two categories; Group 1 with central (hypo-productive group) thrombocytopenia and Group 2 with peripheral (hyper-destructive group). Group1 (n=44) showed median interquartile range (IQR) IPF 8.2 (4.6-16.7), which was significantly lower (p |
| Databáze: | OpenAIRE |
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