Bioactive anti-inflammatory coating for chronic neural electrodes
| Autor: | Yosi Shacham-Diamand, Ari Magal, Roni Hogri, Matti Mintz, Aryeh H. Taub |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Deep brain stimulation
Materials science medicine.drug_class medicine.medical_treatment 0206 medical engineering Anti-Inflammatory Agents Biomedical Engineering 02 engineering and technology Pharmacology Glial scar Rats Sprague-Dawley Biomaterials 03 medical and health sciences 0302 clinical medicine Immune system Glial Fibrillary Acidic Protein medicine Animals Receptor Electrodes 030304 developmental biology Neurons 0303 health sciences Glial fibrillary acidic protein biology Metals and Alloys Interleukin 021001 nanoscience & nanotechnology Receptor antagonist 020601 biomedical engineering Immunohistochemistry Rats Interleukin 1 Receptor Antagonist Protein Interleukin 1 receptor antagonist Immunology Ceramics and Composites biology.protein 0210 nano-technology 030217 neurology & neurosurgery |
| Zdroj: | Journal of Biomedical Materials Research Part A. :1854-1858 |
| ISSN: | 1549-3296 |
| DOI: | 10.1002/jbm.a.34152 |
| Popis: | Chronic electrodes are widely used for brain degenerative and psychiatric diseases such as Parkinson's disease,major depression, and obsessive-compulsive disorder, and for neuronal prosthesis. Brain immune reaction to electrodes in the form of glial scar encapsulates the electrode and reduces the efficacy of deep brain stimulation and neuronal prosthesis.State-of-the-art strategies for improving brain–electrode interface use passive protein coating to "camouflage" the electrode from the immune system. In this study, we actively reduced the brain immune reaction to the chronic electrodes using immune suppressing protein, that is, interleukin (IL)-1 receptor antagonist. IL-1 receptor antagonist-coated electrodes and non coated electrodes were chronically implanted in rats. An additional group of rats was chronically implanted with IL-1 receptor antagonist- and laminin-coated electrodes (as passive protein). Examination of glial scaring 1 and 4 weeks after implantation indicated a significant reduction in the amount of glial scar in the vicinity of the IL-1 receptor antagonist-coated electrode in comparison to both non coated electrode and laminin-coated electrodes. The results strongly suggest that active immune suppressing protein reduces the level of immune reaction to chronic electrodes already after 1 week after implantation and generates less immune reaction than passive protein coating [corrected]. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text